@article{df68b3f1616d4db08fb484c92a70c416,
title = "Indol-1-yl acetic acids as peroxisome proliferator-activated receptor agonists: Design, synthesis, structural biology, and molecular docking studies",
abstract = "A series of novel indole-based PPAR agonists is described leading to discovery of 10k, a highly potent PPAR pan-agonist. The structural biology and molecular docking studies revealed that the distances between the acidic group and the linker, when a ligand was complexed with PPARγ protein, were important for the potent activity. The hydrophobic tail part of 10k makes intensive hydrophobic interaction with the PPARγ protein resulting in potent activity.",
author = "Neeraj Mahindroo and Wang, {Chiung Chiu} and Liao, {Chun Chen} and Huang, {Chien Fu} and Lu, {I. Lin} and Lien, {Tzu Wen} and Peng, {Yi Huei} and Huang, {Wei Jan} and Lin, {Ying Ting} and Hsu, {Ming Chen} and Lin, {Chia Hui} and Tsai, {Chia Hua} and Hsu, {John T.A.} and Xin Chen and Lyu, {Ping Chiang} and Chao, {Yu Sheng} and Wu, {Su Ying} and Hsieh, {Hsing Pang}",
year = "2006",
month = feb,
day = "9",
doi = "10.1021/jm0510373",
language = "English",
volume = "49",
pages = "1212--1216",
journal = "Journal of Medicinal Chemistry",
issn = "0022-2623",
publisher = "American Chemical Society",
number = "3",
}