TY - JOUR
T1 - Independent prognostic factors for fatality in patients with invasive Vibrio cholerae non-O1 infections
AU - Ou, Tsong Yih
AU - Liu, Jien Wei
AU - Leu, Hsieh Shong
PY - 2003/6
Y1 - 2003/6
N2 - To identify independent prognostic factors for fatality, 73 patients with a total of 75 episodes of invasive Vibrio cholerae non -O1 infections treated from July 1998 through October 2001 at 2 medical centers were retrospectively studied. The demographic, laboratory, and clinical information of these patients were collected and analyzed. The overall mortality rate was 36%. Multivariate analysis revealed that severe liver cirrhosis (p=0.003; odds ratio [OR], 14.12, with 95% confidence interval [CI] 2.49-79.91), malignancy (p=0.034; OR, 3.9, with 95% CI 1.11-13. 7), and steroid use (p=0.011; OR, 12.37, with 95% CI 1.79-85.49) were independent risk factors for fatality. These findings suggest that patients at high risk of fatality should be hospitalized and aggressively treated when V. cholerae non-O1 infections develop, and that public education on how to avoid exposure to V. cholerae non-O1 is important for the high-risk population.
AB - To identify independent prognostic factors for fatality, 73 patients with a total of 75 episodes of invasive Vibrio cholerae non -O1 infections treated from July 1998 through October 2001 at 2 medical centers were retrospectively studied. The demographic, laboratory, and clinical information of these patients were collected and analyzed. The overall mortality rate was 36%. Multivariate analysis revealed that severe liver cirrhosis (p=0.003; odds ratio [OR], 14.12, with 95% confidence interval [CI] 2.49-79.91), malignancy (p=0.034; OR, 3.9, with 95% CI 1.11-13. 7), and steroid use (p=0.011; OR, 12.37, with 95% CI 1.79-85.49) were independent risk factors for fatality. These findings suggest that patients at high risk of fatality should be hospitalized and aggressively treated when V. cholerae non-O1 infections develop, and that public education on how to avoid exposure to V. cholerae non-O1 is important for the high-risk population.
KW - Liver cirrhosis
KW - Malignancy
KW - Risk factor
KW - Steroid
KW - Vibrio cholerae non-O1 infection
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UR - http://www.scopus.com/inward/citedby.url?scp=0038152782&partnerID=8YFLogxK
M3 - Article
C2 - 12886963
AN - SCOPUS:0038152782
SN - 0253-2662
VL - 36
SP - 117
EP - 122
JO - Journal of Microbiology, Immunology and Infection
JF - Journal of Microbiology, Immunology and Infection
IS - 2
ER -
