TY - JOUR
T1 - Increased risk of psoriasis following obstructive sleep apnea
T2 - A longitudinal population-based study
AU - Yang, Ya-Wen
AU - Kang, Jiunn Horng
AU - Lin, Herng Ching
PY - 2012/3
Y1 - 2012/3
N2 - Background: This study aims to investigate the risk of psoriasis or psoriatic arthritis in patients with obstructive sleep apnea (OSA) compared with age- and gender-matched unaffected individuals, using a nationally representative population-based dataset. Methods: We used data from the Taiwan "Longitudinal Health Insurance Database 2000." The study consisted of 2258 patients with OSA and 11 255 matched comparison patients as the study cohort. Each selected subject (n= 13 513) in this study was individually traced for a three-year period from their index ambulatory care visits to identify patients who had been diagnosed with psoriasis during the follow-up period. A stratified Cox proportional hazard regression was used to compute the risk of psoriasis between patients with and without OSA. Results: It showed that, of 13 513 sampled subjects, 0.27% (n= 36) had psoriasis during the three-year follow-up period; the percentage was 0.49% and 0.22% for sampled subjects with and without OSA, respectively. After adjusting for the patients' monthly incomes, geographic location, urbanization level, and obesity, the hazard of psoriasis during the three-year follow-up period was 2.30 (95% CI = 1.13-4.69, p= 0.022) times greater for patients with OSA than for comparison patients. Conclusions: Our results suggest that OSA is associated with an increased risk of subsequent psoriasis or psoriatic arthritis.
AB - Background: This study aims to investigate the risk of psoriasis or psoriatic arthritis in patients with obstructive sleep apnea (OSA) compared with age- and gender-matched unaffected individuals, using a nationally representative population-based dataset. Methods: We used data from the Taiwan "Longitudinal Health Insurance Database 2000." The study consisted of 2258 patients with OSA and 11 255 matched comparison patients as the study cohort. Each selected subject (n= 13 513) in this study was individually traced for a three-year period from their index ambulatory care visits to identify patients who had been diagnosed with psoriasis during the follow-up period. A stratified Cox proportional hazard regression was used to compute the risk of psoriasis between patients with and without OSA. Results: It showed that, of 13 513 sampled subjects, 0.27% (n= 36) had psoriasis during the three-year follow-up period; the percentage was 0.49% and 0.22% for sampled subjects with and without OSA, respectively. After adjusting for the patients' monthly incomes, geographic location, urbanization level, and obesity, the hazard of psoriasis during the three-year follow-up period was 2.30 (95% CI = 1.13-4.69, p= 0.022) times greater for patients with OSA than for comparison patients. Conclusions: Our results suggest that OSA is associated with an increased risk of subsequent psoriasis or psoriatic arthritis.
KW - Epidemiology
KW - Inflammation
KW - Obstructive sleep apnea
KW - OSA
KW - Psoriasis
KW - Psoriatic arthritis
UR - http://www.scopus.com/inward/record.url?scp=84862832544&partnerID=8YFLogxK
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U2 - 10.1016/j.sleep.2011.07.018
DO - 10.1016/j.sleep.2011.07.018
M3 - Article
C2 - 22285106
AN - SCOPUS:84862832544
SN - 1389-9457
VL - 13
SP - 285
EP - 289
JO - Sleep Medicine
JF - Sleep Medicine
IS - 3
ER -