Increased risk of depressive disorder following diagnosis with bladder pain syndrome/interstitial cystitis

Joseph J. Keller, Shih Ping Liu, Herng Ching Lin

研究成果: 雜誌貢獻文章同行評審

11 引文 斯高帕斯(Scopus)


Aim Bladder pain syndrome/interstitial cystitis (BPS/IC) is a chronic pain syndrome of unknown etiology that primarily affects women. Using a longitudinal follow-up design, this study aimed to examine the risk of depressive disorder (DD) among women with BPS/IC compared to the general population during a 1-year period following their diagnosis. Method This study used data from the Taiwan "Longitudinal Health Insurance Database." A total of 832 patients with BPS/IC were included in the study group and 4,160 matched non-BPS/IC enrollees were included as the comparison group. Each patient (n = 4,992) was individually tracked for a 1-year period to identify those who subsequently received a diagnosis of DD. Cox proportional hazards regressions (stratified by age group and the index year) were used to estimate the risk of subsequent DD following a diagnosis of BPS/IC. Results We found that during the 1-year follow-up, the incidence rate of DD was 4.69 (95% CI: 3.38-6.34) per 100 person-years in patients with BPS/IC and 0.94 (95% CI: 0.68-1.27) per 100 person-years in comparison patients. The hazard ratio (HR) of DD during the 1-year follow-up period for patients with BPS/IC was 5.06 (95% CI: 3.21-7.96, P <0.001) that of comparison patients after adjusting for patient monthly income, geographic location, and urbanization level. The adjusted HR for DD associated with BPS/IC was 10.33 for patients aged between 40 and 49 (95% CI: 3.68-29.04). Conclusion Our study demonstrated that there is an increased risk for being diagnosed with DD during the first year subsequent to being diagnosed with IC/PBS.
頁(從 - 到)467-471
期刊Neurourology and Urodynamics
出版狀態已發佈 - 6月 2013

ASJC Scopus subject areas

  • 神經病學(臨床)
  • 泌尿科學
  • 醫藥 (全部)


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