TY - JOUR
T1 - Increased Risk of Atopic Diseases in the Siblings of Patients with Autism Spectrum Disorder
T2 - A Nationwide Population-Based Cohort Study
AU - Dai, Ying Xiu
AU - Tai, Ying Hsuan
AU - Chang, Yun Ting
AU - Chen, Tzeng Ji
AU - Chen, Mu Hong
PY - 2019/11/1
Y1 - 2019/11/1
N2 - Several studies have shown a strong association between atopic diseases and autism spectrum disorder (ASD). However, the risk of atopic diseases in individuals having ASD-affected siblings has never been investigated. This nationwide population-based cohort study included 2762 individuals with ASD-affected siblings and 11,048 controls. Diagnoses of atopic diseases, including asthma, atopic dermatitis, allergic rhinitis, and allergic conjunctivitis, were ascertained from 1996 or the birth data to the end of 2011. Individuals with ASD-affected siblings had a higher risk for asthma, atopic dermatitis, allergic rhinitis, allergic conjunctivitis, and multiple atopic diseases compared with controls. In conclusion, individuals with ASD-affected siblings were more likely than were the controls to develop atopic diseases, suggesting shared familial mechanisms underlying the two conditions.
AB - Several studies have shown a strong association between atopic diseases and autism spectrum disorder (ASD). However, the risk of atopic diseases in individuals having ASD-affected siblings has never been investigated. This nationwide population-based cohort study included 2762 individuals with ASD-affected siblings and 11,048 controls. Diagnoses of atopic diseases, including asthma, atopic dermatitis, allergic rhinitis, and allergic conjunctivitis, were ascertained from 1996 or the birth data to the end of 2011. Individuals with ASD-affected siblings had a higher risk for asthma, atopic dermatitis, allergic rhinitis, allergic conjunctivitis, and multiple atopic diseases compared with controls. In conclusion, individuals with ASD-affected siblings were more likely than were the controls to develop atopic diseases, suggesting shared familial mechanisms underlying the two conditions.
KW - Atopy
KW - Autism spectrum disorder
KW - Cohort study
KW - Epidemiology
KW - Sibling
KW - Taiwan’s National Health Insurance Research Database
UR - http://www.scopus.com/inward/record.url?scp=85071029024&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=85071029024&partnerID=8YFLogxK
U2 - 10.1007/s10803-019-04184-w
DO - 10.1007/s10803-019-04184-w
M3 - Article
C2 - 31435817
AN - SCOPUS:85071029024
SN - 0162-3257
VL - 49
SP - 4626
EP - 4633
JO - Journal of Autism and Developmental Disorders
JF - Journal of Autism and Developmental Disorders
IS - 11
ER -