Increased plasma soluble CD40 ligand concentration in pelvic inflammatory disease

Tsung chin Ho, Shun Fa Yang, Po Hui Wang, Long Yau Lin, Yi Torng Tee, Wen Chun Liao, Hsiu-Ju Chang, Hsiu-Ting Tsai

研究成果: 雜誌貢獻文章同行評審

6 引文 斯高帕斯(Scopus)


Background: The role of soluble CD40 ligand (sCD40L) in pelvic inflammatory disease (PID) remains unclear. We sought to determine whether sCD40L was an efficient serum marker as with WBC and CRP in PID patients. Methods: Enzyme-linked immunosorbent assay was used to measure the plasma levels of sCD40L before and after routine protocol treatments in sixty-four PID patients and seventy healthy controls. Results: The level of plasma sCD40L (pg/ml) was significantly elevated in PID patients (1632.83 ± 270.91) compared to that in normal controls (700.33 ± 58.77; p= 0.001) and decreased significantly as compared to that in the same patients (928.77 ± 177.25; p= 0.0001) after they received treatment. The concentration of sCD40L was significantly correlated with the level of plasma C-reactive protein (CRP) in the blood (r = 0.202, p= 0.01, n = 134). When the cutoff level of plasma sCD40L levels was determined to be 1612.26. pg/ml based on ROC, the sensitivity, specificity, and the area under the curve of plasma sCD40L level for predicting PID were 0.26, 0.97, and 0.58 (95% confidence interval: 0.48-0.68), respectively, while the adjusted odds ratio (AOR) with their 95% CI of plasma sCD40L for PID risk was 7.09 (95% CI = 1.14-43.87, p= 0.03). Conclusions: The expression of plasma sCD40L was increased in patients with PID and detection of plasma sCD40L could be useful for the diagnosis of PID.
頁(從 - 到)236-240
期刊Clinica Chimica Acta
出版狀態已發佈 - 1月 1 2015

ASJC Scopus subject areas

  • 生物化學
  • 臨床生物化學
  • 生物化學(醫學)


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