Increased nitric oxide production in hypotensive hemodialysis patients

Shih Hua Lin, Pauling Chu, Fu Chiu Yu, Liang Kuang Diang, Yuh Feng Lin

研究成果: 雜誌貢獻文章同行評審

31 引文 斯高帕斯(Scopus)


A subset of patients on long-term hemodialysis have sustained hypotension, defined as a predialysis systolic pressure of 2 -) and nitrate (NO3 -), the known NO metabolites taken as an index of NO production, in 10 hypotensive patients on long-term hemodialysis. None of them had diabetes, cirrhosis of the liver, congestive heart failure, or infection. Fifteen age and gender-matched normotensive patients on hemodialysis were selected as control subjects. Measurements of plasma levels of nitrite and nitrate based on the Greiss reaction were made. There was no significant difference in hematocrit, serum intact parathyroid hormone, total calcium, inorganic phosphorus, albumin, heart rate, cardiac index, or interdialysis weight gain between these two groups. Plasma nitrite and nitrate levels did not correlate with either predialysis serum creatinine or blood urea nitrogen. The mean arterial pressure (MAP) was significantly lower and plasma nitrite and nitrate levels were significantly higher in chronic hypotensive patients than in normotensive patients (MAP: 68.30 ± 3.24 mmHg vs 95.20 ± 2.44 mmHg, p <0.001; plasma nitrite and nitrate: 72.49 ± 14.41 μmol/L vs 36.42 ± 5.45 μol/L, p <0.05). In addition, MAP from hypotensive and normotensive patients on hemodialysis was inversely correlated with plasma levels of nitrite and nitrate (r = -0.54, p <0.01). It was concluded that enhanced NO production in this subset of patients on hemodialysis may contribute to their chronic hypotension.

期刊ASAIO Journal
出版狀態已發佈 - 9月 1996

ASJC Scopus subject areas

  • 生物物理學
  • 生物工程


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