TY - JOUR
T1 - Incidence of Internal Cancers and Ingested Inorganic Arsenic
T2 - A Seven-Year Follow-up Study in Taiwan
AU - Chiou, Hung Yi
AU - Hsueh, Yu Mei
AU - Liaw, Kuen Fu
AU - Horng, Shan Far
AU - Chiang, Ming Hsi
AU - Pu, Yeong Shiau
AU - Lin, Johnny Shinn Nan
AU - Huang, Chun Hsiung
AU - Chen, Chien Jen
PY - 1995/3/15
Y1 - 1995/3/15
N2 - In order to elucidate the dose-response relationship between ingested inorganic arsenic and internal cancers, a total of 263 patients with black-foot disease and 2293 healthy residents in the endemic area of arseniasis were recruited and followed up for 7 years. The information on consumption of high-arsenic artesian well water, sociodemographic characteristics, life-style and dietary habits, and personal and family history of cancers was obtained through standardized interviews. The occurrence of internal cancers among study subjects was determined through annual health examinations, home visit personal interviews, household registration data checks, and national death certification and cancer registry profile linkages. A dose-response relationship was observed between the long-term arsenic exposure from drinking artesian well water and the incidence of lung cancer, bladder cancer, and cancers of all sites combined after adjustment for age, sex, and cigarette smoking through Cox's proportional hazards regression analysis. Blackfoot disease patients had a significantly increased cancer incidence after adjustment for cumulative arsenic exposure.
AB - In order to elucidate the dose-response relationship between ingested inorganic arsenic and internal cancers, a total of 263 patients with black-foot disease and 2293 healthy residents in the endemic area of arseniasis were recruited and followed up for 7 years. The information on consumption of high-arsenic artesian well water, sociodemographic characteristics, life-style and dietary habits, and personal and family history of cancers was obtained through standardized interviews. The occurrence of internal cancers among study subjects was determined through annual health examinations, home visit personal interviews, household registration data checks, and national death certification and cancer registry profile linkages. A dose-response relationship was observed between the long-term arsenic exposure from drinking artesian well water and the incidence of lung cancer, bladder cancer, and cancers of all sites combined after adjustment for age, sex, and cigarette smoking through Cox's proportional hazards regression analysis. Blackfoot disease patients had a significantly increased cancer incidence after adjustment for cumulative arsenic exposure.
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M3 - Article
C2 - 7882325
AN - SCOPUS:0028919048
SN - 0008-5472
VL - 55
SP - 1296
EP - 1300
JO - Cancer Research
JF - Cancer Research
IS - 6
ER -