@inproceedings{5eb8bffe49a9434e8e32136f592dfac3,
title = "In-Vivo Animal Deep Brain Imaging Using Needle-based Optical Coherence Tomography",
abstract = "Parkinson's disease is a progressive neurodegenerative disease that leads to decreased secretion of nigrostriatal dopamine, which inhibits the activity of the brain's motor cortex, Deep brain stimulation (DBS) is currently the best treatment for patients who do not respond well to drug therapy. The subthalamic nucleus (STN) is the target area for the implanting deep brain electrical stimulation electrodes. Currently, the surgical navigation for DBS depends on pre-operative CT/MRI and intra-operative MER (microelectrode recording) to know whether the electrode has reached the target area, but MER only has non-directional signals. In this project, we developed Optical Coherence Tomography-guided DBS (OCTgDBS) technology, which can obtain real-time, high-resolution images from miniature pig brain, which can assist in the accuracy of navigation and positioning during DBS surgery. Finally, postoperative CT/MRI was used as the basis for positioning in the brain. The results demonstrate that the OCT has a potential to be optical guidance system for DBS.",
keywords = "Deep brain simulation, Optical coherence tomography, Parkinson{\textquoteright}s disease",
author = "Tsai, {Tsung Yi} and Chiou, {De Yi} and Huang, {Chun Chieh} and Jan, {Fu Chiang} and Chang, {Cheng Yi} and Chen, {Shuen Cheng} and Wang, {Yen Chang} and Lo, {Wei Lun} and Chen, {Kai Hsiang} and Yeh, {Chun I.} and Ju, {Yu Ten} and Chiang, {Hung Chih} and Lin, {Chii Wann}",
note = "Publisher Copyright: {\textcopyright} 2023 SPIE.; Biomedical Imaging and Sensing Conference 2023 ; Conference date: 17-04-2023 Through 21-04-2023",
year = "2023",
doi = "10.1117/12.3006576",
language = "English",
series = "Proceedings of SPIE - The International Society for Optical Engineering",
publisher = "SPIE",
editor = "Toyohiko Yatagai",
booktitle = "Biomedical Imaging and Sensing Conference",
address = "United States",
}