@article{e598809ed58142e78b9ddd4d61209d10,
title = "Important Roles of Ring Finger Protein 112 in Embryonic Vascular Development and Brain Functions",
abstract = "Rnf112 is a member of the RING finger protein family. The expression of Rnf112 is abundant in the brain and is regulated during brain development. Our previous study has revealed that Rnf112 can promote neuronal differentiation by inhibiting the progression of the cell cycle in cell models. In this study, we further revealed the important functions of Rnf112 in embryo development and in adult brain. Our data showed that most of the Rnf112−/− embryos exhibited blood vascular defects and died in utero. Upon further investigation, we found that the survival rate of homozygous Rnf112 knockout mice in 129/sv and C57BL/6 mixed genetic background was increased. The survived newborns of Rnf112−/− mice manifested growth retardation as indicated by smaller size and a reduced weight. Although the overall organization of the brain did not appear to be severely affected in Rnf112−/− mice, using in vivo 3D MRI imaging, we found that when compared to wild-type littermates, brains of Rnf112−/− mice were smaller. In addition, Rnf112−/− mice displayed impairment of brain functions including motor balance, and spatial learning and memory. Our results provide important aspects for the study of Rnf112 gene functions.",
keywords = "Brain finger protein, Growth retardation, Memory impairment, Rnf112, Znf179",
author = "Tsou, {Jen Hui} and Yang, {Ying Chen} and Pao, {Ping Chieh} and Lin, {Hui Ching} and Huang, {Nai Kuei} and Lin, {Shih Ting} and Hsu, {Kuei Sen} and Yeh, {Che Ming} and Lee, {Kuen Haur} and Kuo, {Chu Jen} and Yang, {De Ming} and Lin, {Jiann Her} and Chang, {Wen Chang} and Lee, {Yi Chao}",
note = "Funding Information: This work was supported by the National Science Council, Republic of China (NSC 102-2320-B-038-024), Ministry of Science and Technology, Republic of China (MOST 103-2320-B-038-034, MOST 103-2320-B-197-002), and Taipei Medical University (TMU101-AE3-Y24). The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript. We thank the technical services provided by the “Transgenic Mouse Model Core Facility of the National Core Facility Program for Biotechnology, National Science Council” and the “Gene Knockout Mouse Core Laboratory of National Taiwan University Center of Genomic Medicine.” We also thank the technical supports from the Taiwan Mouse Clinic (MOST 104-2325-B-001-011) which is funded by the National Research Program for Biopharmaceuticals (NRPB) at the Ministry of Science and Technology (MOST) of Taiwan. We thank Ms. Christine Chin-jung Hsieh for the English language editing of the manuscript. Publisher Copyright: {\textcopyright} 2016, Springer Science+Business Media New York.",
year = "2017",
doi = "10.1007/s12035-016-9812-7",
language = "English",
volume = "54",
pages = "2286--2300",
journal = "Molecular Neurobiology",
issn = "0893-7648",
publisher = "Humana Press",
number = "3",
}