TY - JOUR
T1 - Importance of dual delivery systems for bone tissue engineering
AU - Farokhi, Mehdi
AU - Mottaghitalab, Fatemeh
AU - Shokrgozar, Mohammad Ali
AU - Ou, Keng Liang
AU - Mao, Chuanbin
AU - Hosseinkhani, Hossein
PY - 2016/3/10
Y1 - 2016/3/10
N2 - Bone formation is a complex process that requires concerted function of multiple growth factors. For this, it is essential to design a delivery system with the ability to load multiple growth factors in order to mimic the natural microenvironment for bone tissue formation. However, the short half-lives of growth factors, their relatively large size, slow tissue penetration, and high toxicity suggest that conventional routes of administration are unlikely to be effective. Therefore, it seems that using multiple bioactive factors in different delivery systems can develop new strategies for improving bone tissue regeneration. Combination of these factors along with biomaterials that permit tunable release profiles would help to achieve truly spatiotemporal regulation during delivery. This review summarizes the various dual-control release systems that are used for bone tissue engineering.
AB - Bone formation is a complex process that requires concerted function of multiple growth factors. For this, it is essential to design a delivery system with the ability to load multiple growth factors in order to mimic the natural microenvironment for bone tissue formation. However, the short half-lives of growth factors, their relatively large size, slow tissue penetration, and high toxicity suggest that conventional routes of administration are unlikely to be effective. Therefore, it seems that using multiple bioactive factors in different delivery systems can develop new strategies for improving bone tissue regeneration. Combination of these factors along with biomaterials that permit tunable release profiles would help to achieve truly spatiotemporal regulation during delivery. This review summarizes the various dual-control release systems that are used for bone tissue engineering.
KW - Bone regeneration
KW - Dual drug delivery
KW - Tissue engineering
UR - http://www.scopus.com/inward/record.url?scp=84957010964&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84957010964&partnerID=8YFLogxK
U2 - 10.1016/j.jconrel.2016.01.033
DO - 10.1016/j.jconrel.2016.01.033
M3 - Article
C2 - 26805518
AN - SCOPUS:84957010964
SN - 0168-3659
VL - 225
SP - 152
EP - 169
JO - Journal of Controlled Release
JF - Journal of Controlled Release
ER -