Importance of dual delivery systems for bone tissue engineering

Mehdi Farokhi, Fatemeh Mottaghitalab, Mohammad Ali Shokrgozar, Keng Liang Ou, Chuanbin Mao, Hossein Hosseinkhani

研究成果: 雜誌貢獻文章同行評審

141 引文 斯高帕斯(Scopus)


Bone formation is a complex process that requires concerted function of multiple growth factors. For this, it is essential to design a delivery system with the ability to load multiple growth factors in order to mimic the natural microenvironment for bone tissue formation. However, the short half-lives of growth factors, their relatively large size, slow tissue penetration, and high toxicity suggest that conventional routes of administration are unlikely to be effective. Therefore, it seems that using multiple bioactive factors in different delivery systems can develop new strategies for improving bone tissue regeneration. Combination of these factors along with biomaterials that permit tunable release profiles would help to achieve truly spatiotemporal regulation during delivery. This review summarizes the various dual-control release systems that are used for bone tissue engineering.
頁(從 - 到)152-169
期刊Journal of Controlled Release
出版狀態已發佈 - 3月 10 2016

ASJC Scopus subject areas

  • 藥學科學


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