@article{790c4f384dcd4f448467c3b5e58028aa,
title = "Impacts of GRIN3A, GRM6 and TPH2 genetic polymorphisms on quality of life in methadone maintenance therapy population",
abstract = "Opioid addiction is a major public health issue worldwide. Methadone maintenance treatment (MMT) is used to detoxify users of illicit opiates, but drug relapse is common and associated with poor quality of life (QoL). This study investigated the associations between the GRIN3A, GRM6, and TPH2 genetic variants and QoL in the MMT population. A total of 319 participants were included in the study, and genotyping of GRIN3A, GRM6, and TPH2 genes was performed using the Sequenom iPLEX. Associations between genotypes and the domains of QoL were examined through posthoc analysis with LSMEANS syntax using SAS 9.1.3. The single nucleotide polymorphisms rs9325202 and rs1487275 in the TPH2 gene were significantly associated with the QoL domain of physical functioning. The least absolute shrinkage and selection operator regression model revealed that the risk allele rs1487275-G was significantly correlated with the domain of physical functioning when clinical characteristics were considered as covariates. The results of the present study illuminate the importance of the genetic basis of QoL in the MMT population, and suggest that genotypes should be considered as a potential QoL indicator.",
author = "Wang, {Ruey Yun} and Chen, {Hsiu Ju} and Huang, {Chieh Liang} and Wang, {Jiun Yi} and Lee, {Tsui Er} and Lee, {Hsiang Yen} and Hung, {Chin Chuan}",
note = "Funding Information: This work was supported by Ministry of Health and Welfare, Taiwan (MOHW107-TDU-B-212-123004)(CCH), China Medical University and Asia University (CMU105-ASIA-24)(CCH), China Medical University (CMU105-S-16)(CCH) and China Medical University Hospital (1 JWO)(RYW). The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript. We thank the National Center for Genome Medicine for the technical/ bioinformatics/statistics support. This manuscript was edited by Wallace Academic Editing. Publisher Copyright: {\textcopyright} 2018 Wang et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.",
year = "2018",
month = jul,
doi = "10.1371/journal.pone.0201408",
language = "English",
volume = "13",
journal = "PLoS ONE",
issn = "1932-6203",
publisher = "Public Library of Science",
number = "7",
}
