@article{97bad1cad55e415a8cc874d65c076e0a,
title = "Impact of treatment delay on survival of oral/oropharyngeal cancers: Results of a nationwide screening program",
abstract = "Background: To assess the impact of treatment delay on survival of oral/oropharyngeal cancer (OSCC). Methods: We followed 5743 OSCCs between 2004 and 2009 from a population-based screening program and ascertained death until the end of 2012. Results: The hazard ratios (HRs) of mortality from OSCC were 1.46 (1.30-1.65) and 1.18 (1.04-1.33) in univariable and multivariable analyses, respectively, for treatment delay longer than 6 weeks compared with that shorter than 3 weeks. The corresponding figures were 1.12 (1.01-1.24) and 1.00 (0.91-1.11) for treatment delay between 3 and 6 weeks. Advancing age (1.01), higher stage (stage II: 1.84, stage III: 2.97, stage IV: 6.33), cancer in tongue (1.37), or hard palate (1.63) had higher HR of mortality (P <.05). However, treatment at medical center had a lower mortality (0.83, 0.75-0.91) than local/regional hospital. Conclusions: Treatment delay longer than 6 weeks for OSCCs detected via a population-based screening program had unfavorable survival.",
keywords = "betel quid chewing, cigarette smoking, oral/oropharyngeal cancer, survival, treatment delay",
author = "Su, {William Wang Yu} and Lee, {Yi Huah} and Yen, {Amy Ming Fang} and Chen, {Sam Li Sheng} and Hsu, {Chen Yang} and Chiu, {Sherry Yueh Hsia} and Fann, {Jean Ching Yuan} and Lee, {Yi Chia} and Chiu, {Han Mo} and Hsiao, {Shu Chun} and Hsu, {Tsui Hsia} and Chen, {Hsiu Hsi}",
note = "Funding Information: This research was approved and funded by the Health Promotion Administration, Ministry of Health and Welfare of Taiwanese government under the program of “Breast cancer, oral cancer, and colorectal cancer screening data monitoring and evaluation research program, Year 2020” (A1081113). The Research Ethics Committee of National Taiwan University Hospital approved this project, and granted a waiver for informed consent (201809041W) pursuant to the regulations of the Institutional Review Board. Publisher Copyright: {\textcopyright} 2020 The Authors. Head & Neck published by Wiley Periodicals LLC. Copyright: Copyright 2021 Elsevier B.V., All rights reserved.",
year = "2021",
month = feb,
doi = "10.1002/hed.26504",
language = "English",
volume = "43",
pages = "473--484",
journal = "Head and Neck",
issn = "1043-3074",
publisher = "John Wiley and Sons Inc.",
number = "2",
}
