TY - JOUR
T1 - Impact of the menstrual cycle on immunologic markers in HIV-infected Taiwanese women
AU - Chao, Kuang Han
AU - Wu, Ming Yih
AU - Chen, Mei Jou
AU - Hung, Chien Ching
AU - Ho, Hong Nerng
N1 - Funding Information:
We thank Miss Shu-Ting Chang for her invaluable technical assistance throughout the course of this study. This study was supported partially by grant DOH89-DC-1005 from the Department of Health, Executive Yuan, Taiwan.
PY - 2006/1/1
Y1 - 2006/1/1
N2 - Objective: This study tested the relationship between cellular immunity and the menstrual cycle in Taiwanese HIV-infected and normal women. Methods: From October 1997 to October 2001, 21 HIV-seropositive women and 30 controls were enrolled in this study. Blood was sampled for hormone profile (estradiol and progesterone) and immunophenotyping with flow cytometry during the follicular and luteal phases. Immunophenotyping included total blood cell count, lymphocyte count, CD4+ cells, CD8+ cells, and their activation markers, including CD25, CD69, HLA-DR, and CD38. Results: The proportion of CD8+ T cells increased during the follicular phase and activating antigens (HLA-DR and CD38) were elevated on CD8+ T cells of HIV-seropositive women. All these alterations seemed unrelated to the menstrual cycle. Conclusions: The CD8+ T cells were increased and activated in women with HIV infection but these alterations were not affected by the menstrual cycle. Therefore, sex hormones seem not to affect the course of HIV infection.
AB - Objective: This study tested the relationship between cellular immunity and the menstrual cycle in Taiwanese HIV-infected and normal women. Methods: From October 1997 to October 2001, 21 HIV-seropositive women and 30 controls were enrolled in this study. Blood was sampled for hormone profile (estradiol and progesterone) and immunophenotyping with flow cytometry during the follicular and luteal phases. Immunophenotyping included total blood cell count, lymphocyte count, CD4+ cells, CD8+ cells, and their activation markers, including CD25, CD69, HLA-DR, and CD38. Results: The proportion of CD8+ T cells increased during the follicular phase and activating antigens (HLA-DR and CD38) were elevated on CD8+ T cells of HIV-seropositive women. All these alterations seemed unrelated to the menstrual cycle. Conclusions: The CD8+ T cells were increased and activated in women with HIV infection but these alterations were not affected by the menstrual cycle. Therefore, sex hormones seem not to affect the course of HIV infection.
KW - HIV-1
KW - Immunologic markers
KW - Menstrual cycle
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U2 - 10.1016/S1028-4559(09)60189-3
DO - 10.1016/S1028-4559(09)60189-3
M3 - Article
C2 - 17272207
AN - SCOPUS:33645750399
SN - 1028-4559
VL - 45
SP - 42
EP - 47
JO - Taiwanese Journal of Obstetrics and Gynecology
JF - Taiwanese Journal of Obstetrics and Gynecology
IS - 1
ER -
