Immunohistochemical analyses of p53 protein expression in breast cancers in Taiwan: A clinicopathologic study

Jan Show Chu, Wei Jei Lee, King Jen Chang, Hey Chi Hsu

研究成果: 雜誌貢獻文章同行評審

6 引文 斯高帕斯(Scopus)

摘要

Immunohistochemical analysis of the p53 protein was performed on paraffin sections of tumor tissue from 210 breast cancer patients. All patients had a follow-up period of more than 5 years. Protein expression of p53 was detected in 64 patients (30.5%). There was significant correlation between p53 protein expression and a high histologic grade (grade III vs grade I/II, 49% vs 23.6%, p = 0.0008) and high mitotic index (≤10/10 hpf vs <10/10 hpf, 42.9% vs 19.6%, p = 0.0004), but not with axillary node status, stromal lymphocytic infiltration, or estrogen receptor or progesterone receptor status. We found that p53 protein expression was not a significant factor in predicting 5-year mortality.

原文英語
頁(從 - 到)237-241
頁數5
期刊Journal of the Formosan Medical Association
96
發行號4
出版狀態已發佈 - 4月 1997
對外發佈

ASJC Scopus subject areas

  • 一般醫學

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