TY - JOUR
T1 - Immunohistochemical analyses of p53 protein expression in breast cancers in Taiwan
T2 - A clinicopathologic study
AU - Chu, Jan Show
AU - Lee, Wei Jei
AU - Chang, King Jen
AU - Hsu, Hey Chi
PY - 1997/4
Y1 - 1997/4
N2 - Immunohistochemical analysis of the p53 protein was performed on paraffin sections of tumor tissue from 210 breast cancer patients. All patients had a follow-up period of more than 5 years. Protein expression of p53 was detected in 64 patients (30.5%). There was significant correlation between p53 protein expression and a high histologic grade (grade III vs grade I/II, 49% vs 23.6%, p = 0.0008) and high mitotic index (≤10/10 hpf vs <10/10 hpf, 42.9% vs 19.6%, p = 0.0004), but not with axillary node status, stromal lymphocytic infiltration, or estrogen receptor or progesterone receptor status. We found that p53 protein expression was not a significant factor in predicting 5-year mortality.
AB - Immunohistochemical analysis of the p53 protein was performed on paraffin sections of tumor tissue from 210 breast cancer patients. All patients had a follow-up period of more than 5 years. Protein expression of p53 was detected in 64 patients (30.5%). There was significant correlation between p53 protein expression and a high histologic grade (grade III vs grade I/II, 49% vs 23.6%, p = 0.0008) and high mitotic index (≤10/10 hpf vs <10/10 hpf, 42.9% vs 19.6%, p = 0.0004), but not with axillary node status, stromal lymphocytic infiltration, or estrogen receptor or progesterone receptor status. We found that p53 protein expression was not a significant factor in predicting 5-year mortality.
KW - breast cancer
KW - immunohistochemistry
KW - p53 protein expression
KW - protein expression
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M3 - Article
C2 - 9136508
AN - SCOPUS:0030994332
SN - 0929-6646
VL - 96
SP - 237
EP - 241
JO - Journal of the Formosan Medical Association
JF - Journal of the Formosan Medical Association
IS - 4
ER -