Immunogenetic aspects of IgE-mediated responses

The reported significant HLA association is consistent with the codominant expression of MHC-linked Ir genes. Similar studies are needed in the case of the other HLA-immune response associations. It seems unlikely that any unique HLA-D genetic sequence will be found only among subjects responding to a particular Ag. It is likely, however, that we will find that a particular sequence is a necessary, but not sufficient, requirement for responsiveness to a particular antigenic epitope. Previous family studies, in which failed to observe parent-to-child transmission of specific immune responsiveness to a particular allergen, suggest that further genetic and/or environmental factors are required for the expression of specific immune responsiveness. These factors include variations in the degree of antigenic exposure. Of particular importance is the need for Ag-specific TcR genes to be expressed in the mature T-cell repertoire. In study of the specific immune response, there have been several studies of the protein and DNA sequences of allergenic proteins; therefore, in regard to understanding the genetics of specific immune responsiveness to allergens and its relationship to atopic diseases, rapid advances can be anticipated over the next several years.