Identification of prognostic factors in patients with cervical cancer and supraclavicular lymph node recurrence

Kung Chu Ho, Chun Chieh Wang, Chyong Huey Lai, Ji Hong Hong, Yi Ting Huang, Kuan Gen Huang, Angel Chao, Gigin Lin, Tzu Chen Yen, J. Timothy Qiu

研究成果: 雜誌貢獻文章同行評審

23 引文 斯高帕斯(Scopus)


Objective: Patients with cervical cancer and supraclavicular lymph nodes (SLN) recurrence have a poor but heterogeneous prognosis. The aim of this study was to identify potential prognostic factors - including FDG-PET results - that may affect survival and treatment outcomes in patients with this group of patients. Methods: Between January 2001 and December 2008, we identified a total of 31 consecutive patients with cervical cancer who had evidence of SLN recurrence. All participants underwent FDG-PET. Survival was measured from the date of documented SLN recurrence. The latency period was defined as the length of time from the date of first diagnosis to the date of SLN recurrence. Results: The median follow-up time was 22.8 months (range: 4.7-105.1). The 3- and 5-year survival rates were 41% and 27.3%, respectively. Patients with intermediate SUV values (between 4.3 and 8) had a significantly better prognosis than subjects with both high (> 8) or low (< 4.3) SUV values (p = 0.004). Latency period < 2 years, SCC-Ag levels ≥ 4 ng/mL, recurrence extend beyond SLN, and SUV of < 4.3 > 8 were significant adverse prognostic factors by multivariate analysis. The 3-year overall survival (OS) rate of patients carrying 0-1 adverse prognostic factors was 90% (low-risk group), while 3-year OS rates for intermediate-risk group (2 factors) and high-risk group (3-4 factors) were 30% and 0%, respectively (p = 0.001). Conclusion: Our results justify the use of PET (accurate extent of relapse and SUV) as a prognostic tool in patients with cervical cancer and SLN recurrence.

頁(從 - 到)253-256
期刊Gynecologic Oncology
出版狀態已發佈 - 11月 2011

ASJC Scopus subject areas

  • 腫瘤科
  • 婦產科


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