Identification of FKBP11 as a biomarker for hepatocellular carcinoma

I. Yin Lin; Chia Hung Yen; Yi Jen Liao; Sey-En Lin; Hon Ping Ma; Yu Jiun Chan; Yi Ming A Chen

Identification of FKBP11 as a biomarker for hepatocellular carcinoma

I. Yin Lin, Chia Hung Yen, Yi Jen Liao, Sey-En Lin, Hon Ping Ma, Yu Jiun Chan, Yi Ming A Chen

研究成果: 雜誌貢獻 › 文章 › 同行評審

摘要

Background: Glycine N-methyltransferase (GNMT) is a tumor suppressor of hepatocellular carcinoma (HCC). High proportions of GNMT knockout mice developed HCC. We previously identified a potential novel marker from Gnmt knockout mice, FK506 binding protein 11 (FKBP11). Here, we determined the clinical usefulness of FKBP11. Patients and Methods: FKBP11 expression levels were analyzed in 123 paired tumor and tumor-Adjacent non-tumorous (TA) tissue samples from patients with HCC and in 29 benign liver samples from patients with hemangioma using quantitative real-time polymerase-chain-reaction. Results: FKBP11 was expressed at a higher level in tumor tissues compared to TA tissues (p

原文	英語
頁（從 - 到）	2763-2770
頁數	8
期刊	Anticancer Research
卷	33
發行號	6
出版狀態	已發佈 - 6月 2013

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癌症研究

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title = "Identification of FKBP11 as a biomarker for hepatocellular carcinoma",

abstract = "Background: Glycine N-methyltransferase (GNMT) is a tumor suppressor of hepatocellular carcinoma (HCC). High proportions of GNMT knockout mice developed HCC. We previously identified a potential novel marker from Gnmt knockout mice, FK506 binding protein 11 (FKBP11). Here, we determined the clinical usefulness of FKBP11. Patients and Methods: FKBP11 expression levels were analyzed in 123 paired tumor and tumor-Adjacent non-tumorous (TA) tissue samples from patients with HCC and in 29 benign liver samples from patients with hemangioma using quantitative real-time polymerase-chain-reaction. Results: FKBP11 was expressed at a higher level in tumor tissues compared to TA tissues (p",

keywords = "FK506 binding protein, FKBP11, FKBP19, GNMT, HCC",

author = "Lin, {I. Yin} and Yen, {Chia Hung} and Liao, {Yi Jen} and Sey-En Lin and Ma, {Hon Ping} and Chan, {Yu Jiun} and Chen, {Yi Ming A}",

year = "2013",

month = jun,

language = "English",

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pages = "2763--2770",

journal = "Anticancer Research",

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TY - JOUR

T1 - Identification of FKBP11 as a biomarker for hepatocellular carcinoma

AU - Lin, I. Yin

AU - Yen, Chia Hung

AU - Liao, Yi Jen

AU - Lin, Sey-En

AU - Ma, Hon Ping

AU - Chan, Yu Jiun

AU - Chen, Yi Ming A

PY - 2013/6

Y1 - 2013/6

N2 - Background: Glycine N-methyltransferase (GNMT) is a tumor suppressor of hepatocellular carcinoma (HCC). High proportions of GNMT knockout mice developed HCC. We previously identified a potential novel marker from Gnmt knockout mice, FK506 binding protein 11 (FKBP11). Here, we determined the clinical usefulness of FKBP11. Patients and Methods: FKBP11 expression levels were analyzed in 123 paired tumor and tumor-Adjacent non-tumorous (TA) tissue samples from patients with HCC and in 29 benign liver samples from patients with hemangioma using quantitative real-time polymerase-chain-reaction. Results: FKBP11 was expressed at a higher level in tumor tissues compared to TA tissues (p

AB - Background: Glycine N-methyltransferase (GNMT) is a tumor suppressor of hepatocellular carcinoma (HCC). High proportions of GNMT knockout mice developed HCC. We previously identified a potential novel marker from Gnmt knockout mice, FK506 binding protein 11 (FKBP11). Here, we determined the clinical usefulness of FKBP11. Patients and Methods: FKBP11 expression levels were analyzed in 123 paired tumor and tumor-Adjacent non-tumorous (TA) tissue samples from patients with HCC and in 29 benign liver samples from patients with hemangioma using quantitative real-time polymerase-chain-reaction. Results: FKBP11 was expressed at a higher level in tumor tissues compared to TA tissues (p

KW - FK506 binding protein

KW - FKBP11

KW - FKBP19

KW - GNMT

KW - HCC

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AN - SCOPUS:84881331173

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JO - Anticancer Research

JF - Anticancer Research

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Identification of FKBP11 as a biomarker for hepatocellular carcinoma

摘要

ASJC Scopus subject areas

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