Hypertension of cardiac origin: A model study

J. C. Hsieh; Shih Ann Chen; Cheng Jeng Tai; John K J Li

Hypertension of cardiac origin: A model study

J. C. Hsieh, Shih Ann Chen, Cheng Jeng Tai, John K J Li

研究成果: 書貢獻/報告類型 › 會議貢獻

摘要

A modified Windkessel model was used to investigate interactions between peripheral resistance and ejection fraction in determining hypertension. Experimental aortic pressure, Pa(t), and aortic flow, Qa(t), data from mongrel dogs with an average of 23 kg were digitized and then incorporated into a three-element lumped arterial system model. By manipulating peripheral resistance (Rs), systemic capacitance (Cs), and Qa(t), the Pa(t) was studied. Results indicated that elevated Pa(t) caused by increased ejection fraction (EF) can be observed within normal or reduced peripheral impedance. Thus anti-hypertensive drugs using vasodilator could not be effective if cardiac origin of hypertension is involved.

原文	英語
主出版物標題	Annual International Conference of the IEEE Engineering in Medicine and Biology - Proceedings
發行者	IEEE
頁面	247
頁數	1
卷	1
ISBN（列印）	0780356756
出版狀態	已發佈 - 1999
對外發佈	是
事件	Proceedings of the 1999 IEEE Engineering in Medicine and Biology 21st Annual Conference and the 1999 Fall Meeting of the Biomedical Engineering Society (1st Joint BMES / EMBS) - Atlanta, GA, USA 持續時間: 10月 13 1999 → 10月 16 1999

其他

其他	Proceedings of the 1999 IEEE Engineering in Medicine and Biology 21st Annual Conference and the 1999 Fall Meeting of the Biomedical Engineering Society (1st Joint BMES / EMBS)
城市	Atlanta, GA, USA
期間	10/13/99 → 10/16/99

ASJC Scopus subject areas

生物工程

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引用此

Hsieh, JC, Chen, SA, Tai, CJ & Li, JKJ 1999, Hypertension of cardiac origin: A model study. 於 Annual International Conference of the IEEE Engineering in Medicine and Biology - Proceedings. 卷 1, IEEE, 頁 247, Proceedings of the 1999 IEEE Engineering in Medicine and Biology 21st Annual Conference and the 1999 Fall Meeting of the Biomedical Engineering Society (1st Joint BMES / EMBS), Atlanta, GA, USA, 10/13/99.

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AB - A modified Windkessel model was used to investigate interactions between peripheral resistance and ejection fraction in determining hypertension. Experimental aortic pressure, Pa(t), and aortic flow, Qa(t), data from mongrel dogs with an average of 23 kg were digitized and then incorporated into a three-element lumped arterial system model. By manipulating peripheral resistance (Rs), systemic capacitance (Cs), and Qa(t), the Pa(t) was studied. Results indicated that elevated Pa(t) caused by increased ejection fraction (EF) can be observed within normal or reduced peripheral impedance. Thus anti-hypertensive drugs using vasodilator could not be effective if cardiac origin of hypertension is involved.

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Hypertension of cardiac origin: A model study

摘要

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