Hypertension and hypercholesterolemia aggregate in nondiabetic children and adolescents with higher fasting plasma glucose levels

Hung Yuan Li, Jung Nan Wei, Wen Ya Ma, Fung Chang Sung, Mao Shin Lin, Cheng Hsin Lin, Chuan Chi Chiang, Lee Ming Chuang

研究成果: 雜誌貢獻文章同行評審

7 引文 斯高帕斯(Scopus)

摘要

Li H-Y, Wei J-N, Ma W-Y, Sung F-C, Lin M-S, Lin C-H, Chiang C-C, Chuang L-M. Hypertension and hypercholesterolemia aggregate in nondiabetic children and adolescents with higher fasting plasma glucose levels. Objective: To investigate how hypertension and hypercholesterolemia aggregate at different fasting plasma glucose (FPG) levels in children aged 6-16 yr. Research design and methods: In a nationwide survey conducted between 1992 and 2000, all schoolchildren aged 6-18 yr with abnormal results in repeated urine samples were included. In this study, we recruited 27 535 students aged 6- to 16-yr whose FPG levels were 90-125 mg/dL. Another 17 907 children were randomly selected as control from schoolchildren with FPG <90 mg/dL by stratification to reflect the age- and sex-specific proportion of the whole student population. Results: The risk of having hypertension or hypercholesterolemia increased at FPG level above 90 mg/dL compared with children with FPG <90 mg/dL [6-10 yr, odd ratios (OR) = 1.51 and 1.82 for FPG 90-99 and 100-125 mg/dL for girls, OR = 1.35 and 2.03 for FPG 90-99 and 100-125 mg/dL for boys; 10-16 yr, OR = 1.24 and 1.66 for FPG 90-99 and 100-125 mg/dL for girls, OR = 1.17 and 1.41 for FPG 90-99 and 100-125 mg/dL for boys, all p < 0.05]. The risk of having both hypertension and hypercholesterolemia elevated at FPG 100-125 mg/dL (6-10 yr, OR = 2.76 for girls and 2.75 for boys; 10-16 yr, OR = 2.19 for girls and 1.74 for boys, all p < 0.05). Conclusions: Aggregation of hypertension, hypercholesterolemia, and abnormal glycemia was found at FPG level above 100 mg/dL, which supported the definition of abnormal glycemia in metabolic syndrome by the International Diabetes Federation in 10- to 16-yr-old children. These findings also suggest that this FPG cutoff is reasonable for 6- to 10-yr-old children.

原文英語
頁(從 - 到)41-49
頁數9
期刊Pediatric Diabetes
12
發行號1
DOIs
出版狀態已發佈 - 2月 2011
對外發佈

ASJC Scopus subject areas

  • 內科學
  • 兒科、圍產兒和兒童健康
  • 內分泌學、糖尿病和代謝

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