@article{fe12066f62b2482c86f5359716b7b92c,
title = "Human papillomavirus genotyping for the eight oncogenic types can improve specificity of HPV testing in women with mildly abnormal Pap results",
abstract = "To evaluate whether human papillomavirus (HPV) genotyping for the selected oncogenic HPV types can improve the efficacy of HPV DNA testing in predicting cervical intraepithelial neoplasia (CIN 2/3) in women with mildly abnormal Pap results, we compared HPV DNA testing and HPV genotyping for eight oncogenic types (16, 18, 31, 33, 35, 45, 52 and 58) in Pap specimens with abnormal results (HSIL, 20 cases; LSIL, 42 cases; ASC-US, 94 cases) and follow-up biopsies. Using consensus primer-mediated PCR assays, HPV DNA was detected in 90% (18/20) of HSIL, 95% (40/42) of LSIL and 64% (60/94) of ASC-US cases. HPV DNA positivity was significantly associated with CIN 2/3/carcinoma (P",
keywords = "ASCUS, Genotyping, HPV, HSIL, Human papillomavirus, LSIL",
author = "Ming Guo and Lin, {Ching Yu} and Yun Gong and Cogdell, {David E.} and Wei Zhang and E. Lin and Nour Sneige",
note = "Funding Information: The study was supported by the University of Texas MD Anderson Cancer Center, Houston TX, USA. We thank King Car Yuanshan Research Institute, I-Lan, Taiwan, for providing EasyChip HPV Blot and technical support for HPV genotyping. We also thank Mr Walter J Pagel, the Department of Scientific Publications, MD Anderson Cancer Center, for editing the article.",
year = "2008",
month = aug,
doi = "10.1038/modpathol.2008.93",
language = "English",
volume = "21",
pages = "1037--1043",
journal = "Modern Pathology",
issn = "0893-3952",
publisher = "Nature Publishing Group",
number = "8",
}
