Human papillomaviral load changes in low-grade squamous intraepithelial lesions of the uterine cervix

C. M. Ho; W. F. Cheng; T. Y. Chu; C. A. Chen; M. H. Chuang; S. F. Chang; C. Y. Hsieh

doi:10.1038/sj.bjc.6603430

Human papillomaviral load changes in low-grade squamous intraepithelial lesions of the uterine cervix

C. M. Ho, W. F. Cheng, T. Y. Chu, C. A. Chen, M. H. Chuang, S. F. Chang, C. Y. Hsieh

研究成果: 雜誌貢獻 › 文章 › 同行評審

9 引文斯高帕斯（Scopus）

摘要

To better predict risk of progression of low-grade squamous intraepithelial lesions (LSILs) of the uterine cervix in women with human papillomavirus (HPV) infections, 294 baseline cervical specimens from women with LSILs were evaluated. Specimens were tested for HPV DNA using hybrid capture 2 (HC2) and PCR-reverse line blotting. 65 LSILs with HPV DNA types 16, 18, 52, or 58 were examined for physical status, E2/E6 ratio and viral load at two time points, along with patient age. Women with LSILs whose viral loads increased between baseline and 6 month follow-up had a 45% risk of developing HSIL (OR = 7.6, 95% CI = 1.9-29.4, P

原文	英語
頁（從 - 到）	1384-1389
頁數	6
期刊	British Journal of Cancer
卷	95
發行號	10
DOIs	https://doi.org/10.1038/sj.bjc.6603430
出版狀態	已發佈 - 11月 20 2006

ASJC Scopus subject areas

癌症研究
腫瘤科

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10.1038/sj.bjc.6603430

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abstract = "To better predict risk of progression of low-grade squamous intraepithelial lesions (LSILs) of the uterine cervix in women with human papillomavirus (HPV) infections, 294 baseline cervical specimens from women with LSILs were evaluated. Specimens were tested for HPV DNA using hybrid capture 2 (HC2) and PCR-reverse line blotting. 65 LSILs with HPV DNA types 16, 18, 52, or 58 were examined for physical status, E2/E6 ratio and viral load at two time points, along with patient age. Women with LSILs whose viral loads increased between baseline and 6 month follow-up had a 45% risk of developing HSIL (OR = 7.6, 95% CI = 1.9-29.4, P ",

keywords = "HPV, Hybrid capture 2, Integration, Low-grade squamous intraepithelial lesions, Viral load",

author = "Ho, {C. M.} and Cheng, {W. F.} and Chu, {T. Y.} and Chen, {C. A.} and Chuang, {M. H.} and Chang, {S. F.} and Hsieh, {C. Y.}",

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AU - Chang, S. F.

AU - Hsieh, C. Y.

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N2 - To better predict risk of progression of low-grade squamous intraepithelial lesions (LSILs) of the uterine cervix in women with human papillomavirus (HPV) infections, 294 baseline cervical specimens from women with LSILs were evaluated. Specimens were tested for HPV DNA using hybrid capture 2 (HC2) and PCR-reverse line blotting. 65 LSILs with HPV DNA types 16, 18, 52, or 58 were examined for physical status, E2/E6 ratio and viral load at two time points, along with patient age. Women with LSILs whose viral loads increased between baseline and 6 month follow-up had a 45% risk of developing HSIL (OR = 7.6, 95% CI = 1.9-29.4, P

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Human papillomaviral load changes in low-grade squamous intraepithelial lesions of the uterine cervix

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