摘要
Nine DNA sequences related to the purine strand of the human centromeric satellite (AATGG)n·(CCAAT)n repeat have been studied by two-dimensional nuclear magnetic resonance spectroscopy. Earlier studies have suggested that the structure of (AATGG)n sequence has an equilibrium between the duplex form and a fold-back form. Structural refinement of d(CAATGG) and its related sequences by an NOE-constrained simulated annealing procedure reveals that the duplex form incorporates dynamic type-I G-A base pairs. 1D exchangeable proton NMR data support this model. The reverse sequence motif (GGTAA) destabilizes the structure.
原文 | 英語 |
---|---|
頁(從 - 到) | 99-103 |
頁數 | 5 |
期刊 | FEBS Letters |
卷 | 347 |
發行號 | 1 |
DOIs | |
出版狀態 | 已發佈 - 6月 20 1994 |
對外發佈 | 是 |
ASJC Scopus subject areas
- 生物物理學
- 結構生物學
- 生物化學
- 分子生物學
- 遺傳學
- 細胞生物學