@article{a722818515444d3b96579dcd8b8c63f9,
title = "High-Definition Transcranial Direct Current with Electrical Theta Burst on Post-Stroke Motor Rehabilitation: A Pilot Randomized Controlled Trial",
abstract = "Background: High-definition transcranial electrical theta burst superimposing direct current stimulation (HD-tDCS-eTBS) not only incorporates the therapeutic advantages of tDCS and TBS but enhances stimulation focality and practicality. However, the applicability of this innovative neuromodulatory device in post-stroke rehabilitation remains uncertain. Objective: This study aimed to assess the efficacy and safety of the HD-tDCS-eTBS on upper extremity (UE) motor function in patients with chronic stroke. Methods: A patient-blinded, randomized controlled study was conducted. Twenty-four participants were randomly assigned into either the active HD-tDCS-eTBS group or sham HD-tDCS-eTBS group. Both groups received 20 minutes of active/sham HD-tDCS-eTBS combined with 30 minutes of conventional UE rehabilitation each time, 3 times a week for 4 weeks. Outcome measures including the Fugl-Meyer Assessment of Upper Extremity, Wolf Motor Function Test, Jebsen-Taylor Hand Function Test, Finger-Nose Test, and Modified Ashworth Scale were assessed before and immediately after the intervention period. Results: Spasticity of shoulder adductor (P =.05), elbow extensor (P =.04), and thumb flexor (P <.01) were significantly reduced in the active HD-tDCS-eTBS group versus the sham group. Nonsignificant trends in the improvements of most other outcome measures were in favor of the active HD-tDCS-eTBS group with moderate to large effect sizes (P =.06–.26, ηp2 = 0.06–0.16). No severe adverse events except for slight skin redness under the stimulus electrode was detected after the HD-tDCS-eTBS. Conclusions: Our findings support that HD-tDCS-eTBS is safe and has therapeutic potential for post-stroke UE motor rehabilitation. Trial registration: ClinicalTrials.gov (ID: NCT04278105).",
keywords = "direct current, high-definition transcranial electrical stimulation, non-invasive brain stimulation, stroke, theta burst stimulation, upper extremity",
author = "Huang, {Yi Jing} and Wang, {Shun Min} and Chieh Chen and Chen, {Chien An} and Wu, {Chun Wei} and Chen, {Jia Jin} and Peng, {Chih Wei} and Lin, {Che Wei} and Huang, {Shih Wei} and Chen, {Shih Ching}",
note = "Funding Information: The author(s) disclosed receipt of the following financial support for the research, authorship, and/or publication of this article: This work was supported by the Ministry of Science and Technology (MOST-108-2321-B-038-002 and MOST-109-2321-B-038-002). The Ministry of Science and Technology did not have a role in designing the study or writing the manuscript. Publisher Copyright: {\textcopyright} The Author(s) 2022.",
year = "2022",
month = sep,
doi = "10.1177/15459683221121751",
language = "English",
volume = "36",
pages = "645--654",
journal = "Neurorehabilitation and Neural Repair",
issn = "1545-9683",
publisher = "SAGE Publications Inc.",
number = "9",
}