TY - JOUR
T1 - High anti-dengue virus activity of the OAS gene family is associated with increased severity of dengue
AU - Simon-Loriere, Etienne
AU - Lin, Ren-Jye
AU - Kalayanarooj, Sita Mint
AU - Chuansumrit, Ampaiwan
AU - Casademont, Isabelle
AU - Lin, Shyr Yi
AU - Yu, Han Pang
AU - Lert-Itthiporn, Worachart
AU - Chaiyaratana, Wathanee
AU - Tangthawornchaikul, Nattaya
AU - Tangnararatchakit, Kanchana
AU - Vasanawathana, Sirijitt
AU - Chang, Bi Lan
AU - Suriyaphol, Prapat
AU - Yoksan, Sutee
AU - Malasit, Prida
AU - Despres, Philipe
AU - Paul, Richard
AU - Lin, Yi Ling
AU - Sakuntabhai, Anavaj
PY - 2015
Y1 - 2015
N2 - Dengue is a mosquito-borne viral disease that afflicts millions of individuals worldwide every year. Infection by any of the 4 dengue virus (DENV) serotypes can result in a spectrum of disease severity. We investigated the impact of variants of interferon-regulated innate immunity genes with a potent antiviral effect on the outcome of DENV infection. We compared the effect of OAS gene family variants on 2 DENV serotypes in cell culture. While both OAS1-p42 and p46 showed antiviral activity against DENV-2, only OAS1-p42 presented anti- DENV-1 activity. Conversely, whereas both OAS3-S381 and R381 variants were able to block DENV-1 infection, the anti-DENV-2 activity observed for OAS3-S381 was largely lost for the R381 variant. By means of an allelic association study of a cohort of 740 patients with dengue, we found a protective effect of OAS3-R381 against shock (odds ratio [OR], 0.37; P
AB - Dengue is a mosquito-borne viral disease that afflicts millions of individuals worldwide every year. Infection by any of the 4 dengue virus (DENV) serotypes can result in a spectrum of disease severity. We investigated the impact of variants of interferon-regulated innate immunity genes with a potent antiviral effect on the outcome of DENV infection. We compared the effect of OAS gene family variants on 2 DENV serotypes in cell culture. While both OAS1-p42 and p46 showed antiviral activity against DENV-2, only OAS1-p42 presented anti- DENV-1 activity. Conversely, whereas both OAS3-S381 and R381 variants were able to block DENV-1 infection, the anti-DENV-2 activity observed for OAS3-S381 was largely lost for the R381 variant. By means of an allelic association study of a cohort of 740 patients with dengue, we found a protective effect of OAS3-R381 against shock (odds ratio [OR], 0.37; P
KW - Cytokine storm
KW - Dengue virus
KW - Genetic susceptibility
KW - Innate immunity
KW - Interferon
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UR - http://www.scopus.com/inward/citedby.url?scp=84954092943&partnerID=8YFLogxK
U2 - 10.1093/infdis/jiv321
DO - 10.1093/infdis/jiv321
M3 - Article
C2 - 26063222
AN - SCOPUS:84954092943
SN - 0022-1899
VL - 212
SP - 2011
EP - 2020
JO - Journal of Infectious Diseases
JF - Journal of Infectious Diseases
IS - 12
ER -
