TY - JOUR
T1 - High agatston calcium score of intracranial carotid artery
T2 - A significant risk factor for cognitive impairment
AU - Kao, Hung Wen
AU - Liou, Michelle
AU - Chung, Hsiao Wen
AU - Liu, Hua Shan
AU - Tsai, Ping Huei
AU - Chiang, Shih Wei
AU - Chou, Ming Chung
AU - Peng, Giia Sheun
AU - Huang, Guo Shu
AU - Hsu, Hsian He
AU - Chen, Cheng Yu
N1 - Publisher Copyright:
Copyright © 2015 Wolters Kluwer Health, Inc. All rights reserved.
PY - 2015
Y1 - 2015
N2 - The effect of intracranial internal carotid artery (ICA) calcification on cognitive impairment is uncertain. Our objective was to investigate whether intracranial ICA calcification is a significant cognitive predictor for cognitive impairment. Global cognition and degrees of intracranial ICA calcification of 579 subjects were assessed with Mini-Mental State Examination (MMSE) and Agatston calcium scoring method, respectively. Other risk factors for cognitive impairment, including age, education level, hypertension, diabetes mellitus, smoking, hyperlipidemia, and body mass index, were documented and analyzed for their associations with cognitive function. In univariate analyses, older age, lower education level, hypertension, diabetes mellitus, and higher intracranial ICA Agatston scores were significantly associated with cognitive impairment. In ordinal logistic regression, only age and total intracranial ICA Agatston score were significant risk factors for cognitive impairment. After adjustment for the other documented risk factors, subjects were 7% (95% CI: 5-10; P
AB - The effect of intracranial internal carotid artery (ICA) calcification on cognitive impairment is uncertain. Our objective was to investigate whether intracranial ICA calcification is a significant cognitive predictor for cognitive impairment. Global cognition and degrees of intracranial ICA calcification of 579 subjects were assessed with Mini-Mental State Examination (MMSE) and Agatston calcium scoring method, respectively. Other risk factors for cognitive impairment, including age, education level, hypertension, diabetes mellitus, smoking, hyperlipidemia, and body mass index, were documented and analyzed for their associations with cognitive function. In univariate analyses, older age, lower education level, hypertension, diabetes mellitus, and higher intracranial ICA Agatston scores were significantly associated with cognitive impairment. In ordinal logistic regression, only age and total intracranial ICA Agatston score were significant risk factors for cognitive impairment. After adjustment for the other documented risk factors, subjects were 7% (95% CI: 5-10; P
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U2 - 10.1097/MD.0000000000001546
DO - 10.1097/MD.0000000000001546
M3 - Article
C2 - 26426620
AN - SCOPUS:84943174557
SN - 0025-7974
VL - 94
SP - e1546
JO - Medicine (United States)
JF - Medicine (United States)
IS - 39
ER -
