Heterogeneity of hepatocellular carcinoma contributes to cancer progression

Kuo Shyang Jeng; Chiung Fang Chang; Wen Juei Jeng; I. Shyan Sheen; Chi Juei Jeng

doi:10.1016/j.critrevonc.2015.01.009

Heterogeneity of hepatocellular carcinoma contributes to cancer progression

Kuo Shyang Jeng, Chiung Fang Chang, Wen Juei Jeng, I. Shyan Sheen, Chi Juei Jeng

研究成果: 雜誌貢獻 › 回顧型文獻 › 同行評審

64 引文斯高帕斯（Scopus）

摘要

Hepatocellular carcinoma (HCC) is a highly heterogeneous disease displaying differences in angiogenesis, extracellular matrix proteins, the immune microenvironment and tumor cell populations. Additionally, genetic variations and epigenetic changes of HCC cells could lead to aberrant signaling pathways, induce cancer stem cells and enhance tumor progression. Thus, the heterogeneity in HCC contributes to disease progression and a better understanding of its heterogeneity will greatly aid in the development of strategies for the HCC treatment.

原文	英語
頁（從 - 到）	337-347
頁數	11
期刊	Critical Reviews in Oncology/Hematology
卷	94
發行號	3
DOIs	https://doi.org/10.1016/j.critrevonc.2015.01.009
出版狀態	已發佈 - 6月 1 2015
對外發佈	是

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血液學
腫瘤科

UN SDG

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10.1016/j.critrevonc.2015.01.009

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title = "Heterogeneity of hepatocellular carcinoma contributes to cancer progression",

abstract = "Hepatocellular carcinoma (HCC) is a highly heterogeneous disease displaying differences in angiogenesis, extracellular matrix proteins, the immune microenvironment and tumor cell populations. Additionally, genetic variations and epigenetic changes of HCC cells could lead to aberrant signaling pathways, induce cancer stem cells and enhance tumor progression. Thus, the heterogeneity in HCC contributes to disease progression and a better understanding of its heterogeneity will greatly aid in the development of strategies for the HCC treatment.",

keywords = "Angiogenesis, Cancer stem cells, Genetic variation, Hepatocellular carcinoma, Heterogeneity, Invasion, Signaling pathway, Tumor microenvironment",

author = "Jeng, {Kuo Shyang} and Chang, {Chiung Fang} and Jeng, {Wen Juei} and Sheen, {I. Shyan} and Jeng, {Chi Juei}",

year = "2015",

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day = "1",

doi = "10.1016/j.critrevonc.2015.01.009",

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journal = "Critical Reviews in Oncology/Hematology",

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T1 - Heterogeneity of hepatocellular carcinoma contributes to cancer progression

AU - Jeng, Kuo Shyang

AU - Chang, Chiung Fang

AU - Jeng, Wen Juei

AU - Sheen, I. Shyan

AU - Jeng, Chi Juei

PY - 2015/6/1

Y1 - 2015/6/1

N2 - Hepatocellular carcinoma (HCC) is a highly heterogeneous disease displaying differences in angiogenesis, extracellular matrix proteins, the immune microenvironment and tumor cell populations. Additionally, genetic variations and epigenetic changes of HCC cells could lead to aberrant signaling pathways, induce cancer stem cells and enhance tumor progression. Thus, the heterogeneity in HCC contributes to disease progression and a better understanding of its heterogeneity will greatly aid in the development of strategies for the HCC treatment.

AB - Hepatocellular carcinoma (HCC) is a highly heterogeneous disease displaying differences in angiogenesis, extracellular matrix proteins, the immune microenvironment and tumor cell populations. Additionally, genetic variations and epigenetic changes of HCC cells could lead to aberrant signaling pathways, induce cancer stem cells and enhance tumor progression. Thus, the heterogeneity in HCC contributes to disease progression and a better understanding of its heterogeneity will greatly aid in the development of strategies for the HCC treatment.

KW - Angiogenesis

KW - Cancer stem cells

KW - Genetic variation

KW - Hepatocellular carcinoma

KW - Heterogeneity

KW - Invasion

KW - Signaling pathway

KW - Tumor microenvironment

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DO - 10.1016/j.critrevonc.2015.01.009

M3 - Review article

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AN - SCOPUS:84928828495

SN - 1040-8428

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SP - 337

EP - 347

JO - Critical Reviews in Oncology/Hematology

JF - Critical Reviews in Oncology/Hematology

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ER -

Heterogeneity of hepatocellular carcinoma contributes to cancer progression

摘要

ASJC Scopus subject areas

UN SDG

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