Heterocyclic bibenzimidazole derivatives as topoisomerase I inhibitors

Song Jin; Jung Sun Kim; Sai Peng Sim; Angela Liu; Daniel S. Pilch; Leroy-Fong Liu; Edmond J. Lavoie

doi:10.1016/S0960-894X(00)00087-1

Heterocyclic bibenzimidazole derivatives as topoisomerase I inhibitors

Song Jin, Jung Sun Kim, Sai Peng Sim, Angela Liu, Daniel S. Pilch, Leroy-Fong Liu, Edmond J. Lavoie

研究成果: 雜誌貢獻 › 文章 › 同行評審

46 引文斯高帕斯（Scopus）

摘要

A series of 2'-heterocyclic derivatives of 5-phenyl-2,5'-1H-bibenzimidazoles were evaluated for topoisomerase I poisoning activity and cytotoxicity. Topo I poisoning activity was associated with 2'-derivatives that possessed a hydrogen atom capable of hydrogen bond formation, suggesting that the interatomic distances between such hydrogen atoms and the heteroatoms on the adjacent benzimidazole influence activity. (C) 2000 Elsevier Science Ltd. All rights reserved.

原文	英語
頁（從 - 到）	719-723
頁數	5
期刊	Bioorganic and Medicinal Chemistry Letters
卷	10
發行號	8
DOIs	https://doi.org/10.1016/S0960-894X(00)00087-1
出版狀態	已發佈 - 4月 2000
對外發佈	是

ASJC Scopus subject areas

生物化學
分子生物學
有機化學
藥物發現
藥學科學

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10.1016/S0960-894X(00)00087-1

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author = "Song Jin and Kim, {Jung Sun} and Sim, {Sai Peng} and Angela Liu and Pilch, {Daniel S.} and Leroy-Fong Liu and Lavoie, {Edmond J.}",

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AU - Liu, Leroy-Fong

AU - Lavoie, Edmond J.

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AB - A series of 2'-heterocyclic derivatives of 5-phenyl-2,5'-1H-bibenzimidazoles were evaluated for topoisomerase I poisoning activity and cytotoxicity. Topo I poisoning activity was associated with 2'-derivatives that possessed a hydrogen atom capable of hydrogen bond formation, suggesting that the interatomic distances between such hydrogen atoms and the heteroatoms on the adjacent benzimidazole influence activity. (C) 2000 Elsevier Science Ltd. All rights reserved.

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Heterocyclic bibenzimidazole derivatives as topoisomerase I inhibitors

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