@article{bc68932af5594d8fbc17be9dfdbdd51c,
title = "Herbal medicines attenuate PD-L1 expression to induce anti-proliferation in obesity-related cancers",
abstract = "Pro-inflammatory hormones and cytokines (leptin, tumor necrosis factor (TNF)-α, and interleukin (IL)-6) rise in obesity. Elevated levels of hormones and cytokines are linked with several comorbidities such as diabetes, heart disease, and cancer. The checkpoint programmed cell death protein 1 (PD-1)/programmed death-ligand 1 (PD-L1) plays an important role in obesity and cancer proliferation. L-thyroxine (T4) and steroid hormones up-regulate PD-L1 accumulation and promote inflammation in cancer cells and diabetics. On the other hand, resveratrol and other herbal medicines suppress PD-L1 accumulation and reduce diabetic effects. In addition, they induce anti-cancer proliferation in various types of cancer cells via different mechanisms. In the current review, we discuss new findings and visions into the antagonizing effects of hormones on herbal medicine-induced anti-cancer properties.",
keywords = "Anoectochilus formosanus hayata, Curcumin, PD-L1, Resveratrol, Steroid hormone, Thyroid hormone",
author = "Yang, {Yu Chen S.H.} and Li, {Zi Lin} and Shih, {Ya Jung} and Bennett, {James A.} and Jaqueline Whang-Peng and Lin, {Hung Yun} and Davis, {Paul J.} and Kuan Wang",
note = "Funding Information: Studies from our group described in this review article were supported in part by a Research Award from the Dr. Ta-Cheng Tung Foundation, by the Chair Professor Research Fund to Dr. J. Whang-Peng and Dr. K. Wang, by the TMU Research Center of Cancer Translational Medicine from The Featured Areas Research Center Program within the framework of the Higher Education Sprout Project by the Ministry of Education (MOE) in Taiwan, by a gift from Dr. Paul J. Davis to Albany College of Pharmacy and Health Sciences, and by a general grant from the Ministry of Science and Technology, Taiwan (MOST 108-2314-B-038-050 to H.Y. Lin). Funding Information: Funding: Studies from our group described in this review article were supported in part by a Research Award from the Dr. Ta-Cheng Tung Foundation, by the Chair Professor Research Fund to Dr. J. Whang-Peng and Dr. K. Wang, by the TMU Research Center of Cancer Translational Medicine from The Featured Areas Research Center Program within the framework of the Higher Education Sprout Project by the Ministry of Education (MOE) in Taiwan, by a gift from Dr. Paul J. Davis to Albany College of Pharmacy and Health Sciences, and by a general grant from the Ministry of Science and Technology, Taiwan (MOST108-2314-B-038-050 to H.Y. Lin). Publisher Copyright: {\textcopyright} 2019 by the authors. Licensee MDPI, Basel, Switzerland.",
year = "2019",
month = dec,
doi = "10.3390/nu11122979",
language = "English",
volume = "11",
journal = "Nutrients",
issn = "2072-6643",
publisher = "Multidisciplinary Digital Publishing Institute (MDPI)",
number = "12",
}
