TY - JOUR
T1 - Hepatotoxicity and hepatocarcinogenicity in rats fed squid with or without exogenous nitrite
AU - Lin, J. K.
AU - Ho, Y. S.
N1 - Funding Information:
to recommentdh at peoplep ay attentionto their P. and BruceW . R. (1979) Volatile N-nitrosaminin es eatingh abits.A nimals tudieso n the hepatotoxicity urineo f normal donoarns do f bladder cancer patients. and carcinogeniciotfy T MAO are now inp rogresisn CancerR esearc3h9 ,829-832. our laboratory. WeisburgeJ.r H. and RaineriR . (1975) Assessmoefn t humane xposuraen dr espone to N-nitroso compounds: a new view on the etiology odf igestive tract cancers. Acknowledgements--Tshtuisd y was supported by the Toxicologayn dA ppliedP harmacolog3y1 , 369-374. National Science Council (8N1S-C04 12-B-002-a8n3d) t he ZeiseSl . H., Dacosta K. AE.,d riseB . M. and Fox J. G. Departmenotf Health Executive Yuan, Taipei, Taiwa(n1,9 86T) ransporot f dimethylamine, a precoufr nsoitrr o-ROC. We thank Mr CS. . Hurngf or his excellent technicasl odimethylaminine,t o stomacho f ferreta nd dog. assistance. Carcinogenes7i,s 7 75-778.
Copyright:
Copyright 2014 Elsevier B.V., All rights reserved.
PY - 1992/8
Y1 - 1992/8
N2 - The popular seafood squid contains high levels of naturally occurring amines such as dimethylamine (DMA) trimethylamine and trimethylamine-N-oxide (TMAO). The hepatotoxicity and hepatocarcinogenicity of squid with or without exogenous nitrite were investigated in rats. Acute necrosis including polymorphogenic neutrophil infiltration, haemorrhage and cholangiofibrosis were observed in the livers of most rats fed squid. Hepatocellular carcinoma (HCC) was induced in two out of 12 rats (16%) by feeding 10% squid in Purina rat chow for 10 months. The incidence of HCC was increased to four out of 10 rats (33%) when 0.3% NaNO2 was added to the above diet. At the end of the experiment a marked elevation of serum γ-glutamate transferase was observed in treated groups, but no significant changes in the activities of serum glutamic-oxaloacetic transaminase and glutamic-pyruvic transaminase were detected. Vitamin C (0.3%) gave partial protection against hepatic damage. The concentration of DMA in squid is estimated to be 0.19%; this concentration did not induce HCC under the experimental conditions used. Therefore it is suggested that another major naturally occurring amine in squid, TMAO, could be one of the important factors involved in the induction of hepatotoxicity and hepatocarcinogenicity in rats.
AB - The popular seafood squid contains high levels of naturally occurring amines such as dimethylamine (DMA) trimethylamine and trimethylamine-N-oxide (TMAO). The hepatotoxicity and hepatocarcinogenicity of squid with or without exogenous nitrite were investigated in rats. Acute necrosis including polymorphogenic neutrophil infiltration, haemorrhage and cholangiofibrosis were observed in the livers of most rats fed squid. Hepatocellular carcinoma (HCC) was induced in two out of 12 rats (16%) by feeding 10% squid in Purina rat chow for 10 months. The incidence of HCC was increased to four out of 10 rats (33%) when 0.3% NaNO2 was added to the above diet. At the end of the experiment a marked elevation of serum γ-glutamate transferase was observed in treated groups, but no significant changes in the activities of serum glutamic-oxaloacetic transaminase and glutamic-pyruvic transaminase were detected. Vitamin C (0.3%) gave partial protection against hepatic damage. The concentration of DMA in squid is estimated to be 0.19%; this concentration did not induce HCC under the experimental conditions used. Therefore it is suggested that another major naturally occurring amine in squid, TMAO, could be one of the important factors involved in the induction of hepatotoxicity and hepatocarcinogenicity in rats.
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U2 - 10.1016/0278-6915(92)90165-H
DO - 10.1016/0278-6915(92)90165-H
M3 - Article
C2 - 1328003
AN - SCOPUS:0026699505
SN - 0278-6915
VL - 30
SP - 695
EP - 702
JO - Food and Chemical Toxicology
JF - Food and Chemical Toxicology
IS - 8
ER -