TY - JOUR
T1 - Hepatitis B virus infection and the risk of male infertility
T2 - A population-based analysis
AU - Su, Fu-Hsiung
AU - Chang, Shih Ni
AU - Sung, Fung Chang
AU - Su, Chien-Tien
AU - Shieh, Ying-Hua
AU - Lin, Cheng Chieh
AU - Yeh, Chih-Ching
N1 - Publisher Copyright:
©2014 by American Society for Reproductive Medicine.
PY - 2014/12/1
Y1 - 2014/12/1
N2 - Objective: To evaluate the risk of male infertility among patients with hepatitis B virus (HBV) infection. Design: A nationwide, population-based cohort study. Setting: Not applicable. Patient(s): Men infected with HBV (n = 5,138) and men without HBV infection (n = 25,690). Intervention(s): None. Main Outcome Measure(s): Male infertility, as defined by the International Classification of Diseases, Ninth Revision, Clinical Modification. Result(s): The incidence of infertility was 1.59 times higher in patients with HBV infection than in those without HBV infection (2.21 vs. 1.39 per 1,000 person-years). The risk of developing infertility remained significant among patients with HBV infection (hazard ratio 1.52, 95% confidence interval 1.20-1.92) after adjusting for covariates in a multivariate Cox proportional hazards model. Conclusion(s): The data show an increased incidence and risk of infertility among men with HBV infection compared with men without HBV.
AB - Objective: To evaluate the risk of male infertility among patients with hepatitis B virus (HBV) infection. Design: A nationwide, population-based cohort study. Setting: Not applicable. Patient(s): Men infected with HBV (n = 5,138) and men without HBV infection (n = 25,690). Intervention(s): None. Main Outcome Measure(s): Male infertility, as defined by the International Classification of Diseases, Ninth Revision, Clinical Modification. Result(s): The incidence of infertility was 1.59 times higher in patients with HBV infection than in those without HBV infection (2.21 vs. 1.39 per 1,000 person-years). The risk of developing infertility remained significant among patients with HBV infection (hazard ratio 1.52, 95% confidence interval 1.20-1.92) after adjusting for covariates in a multivariate Cox proportional hazards model. Conclusion(s): The data show an increased incidence and risk of infertility among men with HBV infection compared with men without HBV.
KW - Hepatitis B virus
KW - Male infertility
KW - Population-based study
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U2 - 10.1016/j.fertnstert.2014.09.017
DO - 10.1016/j.fertnstert.2014.09.017
M3 - Article
C2 - 25439807
AN - SCOPUS:84922014631
SN - 0015-0282
VL - 102
SP - 1677
EP - 1684
JO - Fertility and Sterility
JF - Fertility and Sterility
IS - 6
ER -
