Hepatic failure related to itraconazole use successfully treated by corticosteroids

Horng Yuan Lou, Chia Lang Fang, Sheng Uei Fang, Cheng Tiong, Yang Chih Cheng, Chun Chao Chang

研究成果: 雜誌貢獻文章同行評審

7 引文 斯高帕斯(Scopus)


Background: Itraconazole is believed to carry a low risk of hepatic toxicity owing to its low affinity for the human P-450 enzyme. Therefore, hepatic failure caused by itraconazole is exceedingly rare. Objectives: We report the case of a 46-year-old woman who developed hepatic failure related to itraconazole that was administered for the treatment of onychomycosis. Her condition deteriorated after withdrawal of the drug, followed solely by supportive care initially. Case Report: Treatment with corticosteroids was started 10 days after her admission, and her condition gradually improved. Unfortunately, her condition worsened when the dosage of corticosteroids was abruptly decreased. Ultimately, her condition improved with appropriate adjustments of corticosteroid dosage. Discussion: We conclude that corticosteroid therapy may be effective for itraconazole-induced hepatitis, especially in those patients who do not respond to conservative treatment. Notably, any decrease in the dosage should be performed with caution. We also recommend that close monitoring of liver function is mandatory during the use of itraconazole.

頁(從 - 到)843-846
期刊Hepatitis Monthly
出版狀態已發佈 - 10月 2011

ASJC Scopus subject areas

  • 肝病
  • 傳染性疾病


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