Heavy smoking, reduced olanzapine levels, and treatment effects: A case report

Chih Chiang Chiu, Mong Liang Lu, Ming Chyi Huang, Kun P. Chen

研究成果: 雜誌貢獻文章同行評審

14 引文 斯高帕斯(Scopus)


A 30-year-old schizophrenic male patient, a heavy smoker, was successfully treated with olanzapine 15 mg/d during hospitalization. His cigarette consumption increased rapidly from 12 to 80 cigarettes per day following his discharge. Ten days later, his delusion of persecution, levels of hostility, and aggressive behavior worsened, while the plasma levels of olanzapine concurrently decreased. Based on our observations of this case, we suggest that the reduced levels of plasma olanzapine and exacerbated clinical symptoms are closely related to the increased consumption of cigarettes. A possible explanation would be that heavy smoking induced cytochrome P4501A2, the major enzyme involved in olanzapine metabolism. Therefore, patients who smoke should be closely monitored for their cigarette consumption when the dosage of olanzapine is adjusted.

頁(從 - 到)579-581
期刊Therapeutic Drug Monitoring
出版狀態已發佈 - 10月 2004

ASJC Scopus subject areas

  • 生物化學、遺傳與分子生物學 (全部)
  • 生物化學
  • 健康、毒理學和誘變
  • 藥學(醫學)
  • 公共衛生、環境和職業健康
  • 藥理
  • 毒理學


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