Haplotype of ESR1 and PPARD Genes Is Associated with Higher Anthropometric Changes in Han Chinese Obesity by Adjusting Dietary Factors—An 18-Month Follow-Up

Yu Min Huang, Weu Wang, Po Pin Hsieh, Hsin Hung Chen

研究成果: 雜誌貢獻文章同行評審

1 引文 斯高帕斯(Scopus)

摘要

The obesity genetic effect may play a major role in obesogenic environment. A combined case–control and an 18-month follow-up were carried out, including a total of 311 controls and 118 obese cases. All participants were aged in the range of 20–55 y/o. The body mass index (BMI) of obese cases and normal controls was in the range of 27.0–34.9 and 18.5–23.9 kg/m2, respectively. The rs712221 on Estrogen receptor1 (ESR1) and rs2016520 on Peroxisome proliferator–activated receptor delta (PPARD) showed significant associations with obesity. The TT (odds ratio (OR): 2.42; 95% confidence interval (CI): 1.46–4.01) and TT/TC (OR: 2.80; 95% CI: 1.14–6.85) genotypes on rs712221 and rs2016520 had significantly higher obesity risks, respectively. Moreover, the synergic effect of these two risk SNPs (2-RGH) exhibited an almost geometrical increase in obesity risk (OR: 7.00; 95% CI: 2.23–21.99). Obese individuals with 2-RGH had apparently higher changes in BMI increase, body weight gain and dietary fiber intake but a lower total energy intake within the 18-month follow-up.
原文英語
文章編號4425
期刊Nutrients
14
發行號20
DOIs
出版狀態已發佈 - 10月 2022

ASJC Scopus subject areas

  • 食品科學
  • 營養與營養學

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