Gut butyrate-producers confer post-infarction cardiac protection

Hung-Chih Chen, Yen-Wen Liu, Kuan-Cheng Chang, Yen-Wen Wu, Yi-Ming Chen, Yu-Kai Chao, Min-Yi You, David J. Lundy, Chen-Ju Lin, Marvin L. Hsieh, Yu-Che Cheng, Ray P. Prajnamitra, Po-Ju Lin, Shu-Chian Ruan, David Hsin-Kuang Chen, Edward S. C. Shih, Ke-Wei Chen, Shih-Sheng Chang, Cindy M. C. Chang, Riley PuntneyAmy Wu Moy, Yuan-Yuan Cheng, Hsin-Yuan Chien, Jia-Jung Lee, Deng-Chyang Wu, Ming-Jing Hwang, Jennifer Coonen, Timothy A. Hacker, C-L. Eric Yen, Federico E. Rey, Timothy J. Kamp, Patrick C. H. Hsieh

研究成果: 雜誌貢獻文章同行評審


The gut microbiome and its metabolites are increasingly implicated in several cardiovascular diseases, but their role in human myocardial infarction (MI) injury responses have yet to be established. To address this, we examined stool samples from 77 ST-elevation MI (STEMI) patients using 16 S V3-V4 next-generation sequencing, metagenomics and machine learning. Our analysis identified an enriched population of butyrate-producing bacteria. These findings were then validated using a controlled ischemia/reperfusion model using eight nonhuman primates. To elucidate mechanisms, we inoculated gnotobiotic mice with these bacteria and found that they can produce beta-hydroxybutyrate, supporting cardiac function post-MI. This was further confirmed using HMGCS2-deficient mice which lack endogenous ketogenesis and have poor outcomes after MI. Inoculation increased plasma ketone levels and provided significant improvements in cardiac function post-MI. Together, this demonstrates a previously unknown role of gut butyrate-producers in the post-MI response.
期刊Nature Communications
出版狀態已發佈 - 2023


深入研究「Gut butyrate-producers confer post-infarction cardiac protection」主題。共同形成了獨特的指紋。