Gold-stabilized carboxymethyl dextran nanoparticles for image-guided photodynamic therapy of cancer

Minchang Lee, Hansang Lee, N. Vijayakameswara Rao, Hwa Seung Han, Sangmin Jeon, Jueun Jeon, Seokyung Lee, Seunglee Kwon, Yung Doug Suh, Jae Hyung Park

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15 引文 斯高帕斯(Scopus)

摘要

Photodynamic therapy (PDT) has been extensively investigated to treat cancer since it induces cell death through the activation of photosensitizers by light. However, its success has been hampered by the insufficient selectivity of photosensitizers to tumor tissues. In an attempt to increase the therapeutic efficacy of PDT by targeting the photosensitizer specifically to the tumor site, we prepared chlorin e6 (Ce6)-loaded gold-stabilized carboxymethyl dextran nanoparticles (Ce6-GS-CNPs). Ce6-GS-CNPs possessed highly stable nanostructures and no significant change was observed in their particle size in the presence of serum for 6 days. When Ce6-GS-CNPs were intravenously injected into tumor-bearing mice, they exhibited prolonged circulation in the body and gradually accumulated in the tumor tissue. Under laser irradiation of the tumor site which could be recognized by the near-infrared fluorescence imaging system, Ce6-GS-CNPs effectively suppressed tumor growth. Overall, Ce6-GS-CNPs might have potential as nanomedicine for image-guided photodynamic cancer therapy.
原文英語
頁(從 - 到)7319-7327
頁數9
期刊Journal of Materials Chemistry B
5
發行號35
DOIs
出版狀態已發佈 - 2017

ASJC Scopus subject areas

  • 一般化學
  • 生物醫學工程
  • 一般材料科學

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