TY - JOUR
T1 - Glypican-3 Expression in Breast Cancer
AU - Ching-Hua Tsai, null
AU - Wei-Ti Su, null
AU - Shyr-Ming Sheen-Chen, null
AU - Jiun-Lung Liang, null
AU - Hsien-Wen Hsu, null
AU - Wei-Ting Chen, null
AU - Eng-Yen Huang, null
AU - Chao-Cheng Huang, null
AU - Kung-Ming Rau, null
AU - Rei-Ping Tang, null
PY - 2015
Y1 - 2015
N2 - Background: The protein Glypican-3 has been found in various types of tumors and has shown promise as a tumor marker. However, there is still very limited information about the role of Glypican-3 in breast cancer. Tissue microarray (TMA) analyzes thousands of specimens in parallel with minimal damage to the origin blocks. The purpose of this study was to ascertain the role of Glypican-3 status in breast cancer using TMA. Materials and Methods: Archival tissue specimens from 99 patients with primary invasive breast cancer were analyzed for Glypican-3 expression by immunohistochemical staining with TMA. The results were compared to clinicopathologic data by the use of multivariate analysis. Results: TNM stage was significantly related to the overall 5-year survival rate. Nevertheless, Glypican-3 expression has no significant relationship to overall five-year survival. Conclusions: Immunohistochemical staining with TMA was convenient and feasible for analyzing Glypican-3 expression status in breast cancer. However, our preliminary results show that Glypican-3 expression had no significant prognostic value in breast cancer.
AB - Background: The protein Glypican-3 has been found in various types of tumors and has shown promise as a tumor marker. However, there is still very limited information about the role of Glypican-3 in breast cancer. Tissue microarray (TMA) analyzes thousands of specimens in parallel with minimal damage to the origin blocks. The purpose of this study was to ascertain the role of Glypican-3 status in breast cancer using TMA. Materials and Methods: Archival tissue specimens from 99 patients with primary invasive breast cancer were analyzed for Glypican-3 expression by immunohistochemical staining with TMA. The results were compared to clinicopathologic data by the use of multivariate analysis. Results: TNM stage was significantly related to the overall 5-year survival rate. Nevertheless, Glypican-3 expression has no significant relationship to overall five-year survival. Conclusions: Immunohistochemical staining with TMA was convenient and feasible for analyzing Glypican-3 expression status in breast cancer. However, our preliminary results show that Glypican-3 expression had no significant prognostic value in breast cancer.
KW - 乳癌
KW - 組織微陣列
KW - glypican-3
KW - breast cancer
KW - tissue microarray
U2 - 10.6323/JCRP.2015.2.4.2
DO - 10.6323/JCRP.2015.2.4.2
M3 - Article
SN - 2311-3006
VL - 2
SP - 285
EP - 292
JO - 台灣癌症醫學雜誌
JF - 台灣癌症醫學雜誌
IS - 4
ER -
