Genome-Wide Gene Expression Analysis to Identify Epistatic Gene-Pairs Associated with Prognosis of Breast Cancer

Breast cancer is the most common cancer in women in the world. According to the most recent estimates from GLOBOCAN published by the International Agency for Research on Cancer (IARC) , there were nearly 1.7 million new breast cancer cases diagnosed in 2012(25.2% of all cancers in women) and 6.3 millions have been diagnosed with breast cancer in 2007-2012. Breast cancer incidence has been increasing by more than 20% and mortality increased by 14% since 2008 and is the most common cause of cancer death in women in less developed regions (324,000 deaths, 14.3% of total). Breast cancer is less favorable in the underdeveloped countries due to less advanced medical diagnosis and treatments. Therefore a good diagnosis/prognosis would help to prevent as well as provide effective clinical treatments.