Genetic characteristics of azithromycin-resistant Neisseria gonorrhoeae collected in Hyogo, Japan during 2015-2019

Makiko Miura, Katsumi Shigemura, Kayo Osawa, Noriko Nakanishi, Ryohei Nomoto, Reo Onishi, Hiroyuki Yoshida, Toru Sawamura, Shiuh Bin Fang, Yi Te Chiang, Shian Ying Sung, Kuan Cho Chen, Takayuki Miyara, Masato Fujisawa

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2 引文 斯高帕斯(Scopus)

摘要

Introduction. Azithromycin (AZM) is a therapeutic drug for sexually transmitted infections and is used for Neisseria gonorrhoeae when first- and second-line drugs are not available. Recently, the susceptibility of N. gonorrhoeae against AZM has been decreasing worldwide. Hypothesis/Gap Statement. Azithromycin-resistance (AZM-R) rates among N. gonorrhoeae in Japan are increasing, and the gene mutations and epidemiological characteristics of AZM-R in N. gonorrhoeae have not been fully investigated. Aim. We determined the susceptibility to AZM and its correlation with genetic characteristics of N. gonorrhoeae. Methodology. We investigated the susceptibility to AZM and genetic characteristics of N. gonorrhoeae. Mutations in domain V of the 23S rRNA gene and mtrR were examined in 93 isolates, including 13 AZM-R isolates. Spread and clonality were examined using sequence types (STs) of multi-antigen sequence typing for N. gonorrhoeae (NG-MAST), and whole genome analysis (WGA) to identify single nucleotide polymorphisms. Results. The number of AZM-R isolates increased gradually from 2015 to 2019 in Hyogo (P=0.008). C2599T mutations in 23S rRNA significantly increased in AZM-R isolates (P
原文英語
文章編號001533
期刊Journal of Medical Microbiology
71
發行號6
DOIs
出版狀態已發佈 - 2022

ASJC Scopus subject areas

  • 微生物學
  • 微生物學(醫學)

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