Genetic aspects of asthma

P. S. Gao, S. K. Huang

研究成果: 雜誌貢獻回顧型文獻同行評審

14 引文 斯高帕斯(Scopus)


Over the last few years, a significant progress has been made in understanding of the genetic basis of asthma. This has led to the identification of several chromosomal regions and loci showing linkage to and association with asthma and asthma-linked phenotypes. Recent positional cloning approaches have also been informative in identifying several strong candidate genes for asthma. The next challenge will involve validation of these findings and, importantly, identification of the functional basis in the pathophysiology of asthma. This review will describe the power of positional cloning for the identification of asthma genes, highlight the functional importance of the genetic variants, and address the gene-gene and gene-environment interactions that are pertinent to this challenging field.

頁(從 - 到)121-134
期刊Panminerva Medica
出版狀態已發佈 - 6月 2004

ASJC Scopus subject areas

  • 一般醫學


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