Genetic analysis identifies the role of HLF in renal cell carcinoma

CHAO YUAN HUANG, SHU PIN HUANG, YU MEI HSUEH, LIH CHYANG CHEN, TE LING LU, BO YING BAO

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9 引文 斯高帕斯(Scopus)

摘要

Background/Aim: Circadian rhythm is an internal clock that regulates the cycles of many biological functions. Epidemiological studies have linked aberrant circadian rhythm to an increased susceptibility to cancer and poor patient prognosis. However, there remains a gap in our understanding of genetic variants related to the circadian pathway in renal cell carcinoma (RCC) progression. Patients and Methods: We examined the associations of 150 single nucleotide polymorphisms (SNPs) in 12 core circadian pathway genes with RCC risk and survival in 630 patients with RCC and controls. Results: After adjusting for multiple comparisons and performing multivariate analyses, we found that the HLF rs6504958 polymorphism was significantly associated with RCC risk (q<0.05), whereas, no SNP association was significant for survival. Furthermore, the rs6504958 G allele was associated with reduced expression of HLF; consequently, a lower HLF expression was correlated with more advanced RCC. Moreover, a metaanalysis of six kidney cancer gene expression datasets demonstrated that an elevated HLF expression was associated with a favorable prognosis in patients with RCC (hazard ratio=0.70, 95% confidence interval=0.65-0.76, p<0.001). Conclusion: These findings implicate the potential protective role of HLF in the progression of RCC. © 2020 International Institute of Anticancer Research. All rights reserved.
原文英語
頁(從 - 到)827-833
頁數7
期刊Cancer Genomics and Proteomics
17
發行號6
DOIs
出版狀態已發佈 - 12月 2020

ASJC Scopus subject areas

  • 生物化學
  • 分子生物學
  • 遺傳學
  • 癌症研究

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