Gender Difference in the Prognostic Role of Interleukin 6 in Oral Squamous Cell Carcinoma

Chih Jung Chen, Wen Wei Sung, Yueh Min Lin, Mu Kuan Chen, Ching Hsiao Lee, Huei Lee, Kun Tu Yeh, Jiunn Liang Ko

研究成果: 雜誌貢獻文章同行評審

36 引文 斯高帕斯(Scopus)

摘要

Background: Interleukin 6 (IL6) plays an important role in immunoregulation and tumorigenesis in human cancers. Oral squamous cell carcinoma (OSCC) is a malignant tumor of the oral cavity with a male predominant tendency and a poor clinical prognosis. Due to the relatively few cases in females, the gender difference of prognostic markers for OSCC is seldom discussed. Methods: In this study, we used immunohistochemical staining methods to investigate the associations between IL6 expression and the clinicopathological characteristics of OSCC. In addition, we collected 74 female and 263 male OSCC patients for evaluation. Results: High IL6 expression in tumor cells was significantly associated OSCC patient characteristics including female gender (P<0.001), high lymph node metastatic rate (P = 0.007), and poor tumor differentiation (P = 0.008). Tumor-expressed IL6 had prognostic role in male OSCC patients as defined by the log-rank test (P = 0.014), but not in female patients (P = 0.959). In male OSCC patients, high IL6 expression in tumor cells was associated with poor prognosis (P = 0.025) and a 1.454-fold higher death risk, as determined by Cox regression. Conclusions: High IL6 expression in tumor cells was therefore significantly associated with aggressive clinical manifestations and might be an independent survival predictor, particularly in male OSCC patients. © 2012 Chen et al.
原文英語
文章編號e50104
期刊PLoS ONE
7
發行號11
DOIs
出版狀態已發佈 - 11月 21 2012
對外發佈

ASJC Scopus subject areas

  • 一般生物化學,遺傳學和分子生物學
  • 一般農業與生物科學
  • 多學科

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