Galectins and Host–Pathogen Interactions: The roles in viral infections

Sheng Fang Wang, Hung Lin Chen, Fu Tong Liu

研究成果: 雜誌貢獻回顧型文獻同行評審

摘要

Galectins, a family of carbohydrate-binding proteins, play crucial roles in the host–virus interaction landscape. This review explores the multifaceted contributions of endogenous galectins to various stages of the viral lifecycle, including attachment, replication, assembly, and release of progeny virions. Recent studies have indicated that viral infections can induce the expression and secretion of specific galectins, with elucidated signaling pathways in some cases, enhancing our understanding of their regulatory mechanisms. While many studies have focused on the effects of exogenous recombinant galectins, there is growing interest in the intrinsic functions of endogenous galectins, particularly through genetic alterations in cellular models. This review highlights the need for further research to uncover the complex roles of galectins in modulating viral infections and emphasizes their potential as therapeutic targets in the fight against viral diseases. Understanding these interactions could pave the way for novel strategies to enhance host defense mechanisms and mitigate viral pathogenesis.
原文英語
文章編號101911
期刊Seminars in Immunology
76
DOIs
出版狀態已發佈 - 11月 2024

ASJC Scopus subject areas

  • 免疫學和過敏
  • 免疫學

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