GABA concentrations in the human anterior cingulate cortex predict negative BOLD responses in fMRI

Georg Northoff; Martin Walter; Rolf F. Schulte; Johannes Beck; Ulrike Dydak; Anke Henning; Heinz Boeker; Simone Grimm; Peter Boesiger

doi:10.1038/nn2001

GABA concentrations in the human anterior cingulate cortex predict negative BOLD responses in fMRI

Georg Northoff, Martin Walter, Rolf F. Schulte, Johannes Beck, Ulrike Dydak, Anke Henning, Heinz Boeker, Simone Grimm, Peter Boesiger

研究成果: 雜誌貢獻 › 文章 › 同行評審

314 引文斯高帕斯（Scopus）

摘要

The human anterior cingulate cortex (ACC) is part of the default-mode network that shows predominant negative blood oxygen level-dependent (BOLD) responses in functional magnetic resonance imaging (fMRI). We combined fMRI during emotional processing and resting-state magnetic resonance spectroscopy measurements and observed that the concentration of GABA in the ACC specifically correlated with the amount of negative BOLD responses in the very same region. Our findings show that default-mode network negative BOLD responses during emotions are mediated by GABA.

原文	英語
頁（從 - 到）	1515-1517
頁數	3
期刊	Nature Reviews Neuroscience
卷	10
發行號	12
DOIs	https://doi.org/10.1038/nn2001
出版狀態	已發佈 - 12月 2007
對外發佈	是

ASJC Scopus subject areas

一般神經科學

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10.1038/nn2001

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AU - Boeker, Heinz

AU - Grimm, Simone

AU - Boesiger, Peter

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GABA concentrations in the human anterior cingulate cortex predict negative BOLD responses in fMRI

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