摘要
Hyperthermia is one of the promising treatments for cancer therapy. However, the development of a magnetic fuid agent that can selectively target a tumor and efficiently elevate temperature while exhibiting excellent biocompatibility still remains challenging. Here a new core-shell nanostructure consisting of inorganic iron oxide (Fe3O4) nanoparticles as the core, organic alginate as the shell, and cell-targeting ligands (ie, D-galactosamine) decorated on the outer surface (denoted as Fe3O4@Alg-GA nanoparticles) was prepared using a combination of a pre-gel method and coprecipitation in aqueous solution. After treatment with an AC magnetic feld, the results indicate that Fe3O4@Alg-GA nanoparticles had excellent hyperthermic efficacy in a human hepatocellular carcinoma cell line (HepG2) owing to enhanced cellular uptake, and show great potential as therapeutic agents for future in vivo drug delivery systems.
原文 | 英語 |
---|---|
頁(從 - 到) | 3315-3328 |
頁數 | 14 |
期刊 | International Journal of Nanomedicine |
卷 | 10 |
DOIs | |
出版狀態 | 已發佈 - 5月 4 2015 |
ASJC Scopus subject areas
- 生物物理學
- 生物工程
- 生物材料
- 藥學科學
- 藥物發現
- 有機化學