5 引文 斯高帕斯(Scopus)

摘要

Despite a single drug, Aducanumab, recently approved by the U.S. Food and Drug Administration for Alzheimer's disease (AD)-modifying treatments, the development of non-invasive, highly sensitive, and early screening devices to halt the disease remains a critical challenge. In this study, an electrochemical biosensor for amyloid-β (42) oligomers (AβOs) detection based on immobilized DNA aptamer onto vertical aligned tin disulfide nanosheets (SnS2 NSs) is developed for the first time. Highly crystalline, uniform, and vertical aligned SnS2 NSs were synthesized via a facile chemical vapor deposition (CVD) process. The sensing platform, comprising of Aβ (42)-specific capture aptamer covalently immobilized onto self-assembled-3-mercaptopropyl-trimethoxysilane (MPTMS)-SnS2 binds specifically toward AβOs. The biosensor can detect the AβOs at wide linear concentration range from 10-4 to 103 ng/mL with a low limit of detection (LOD) of 238.9 fg/mL and 56.9 fg/mL in physiological buffer and human serum (HS), respectively. The developed biosensor was successfully used to detect AβOs in the mice blood serum samples indicating its potential for clinical application in Alzheimer's biomarker detection. Moreover, the SnS2-aptasensor shows good stability, selectivity, and interference-resistance. The predominant edge-plane active site and energetically preference for vertical SnS2 over its planar structure were unveiled by density-functional theory calculations which emphasize the advantages of applying nanomaterial with vertical orientated configuration into electrocatalytic reaction. The as-designed SnS2-aptasensor could shed light not only on multifunctional electrochemical biosensor design, but also for advancements on future Alzheimer's diagnosis.
原文英語
文章編號139394
期刊Chemical Engineering Journal
452
DOIs
出版狀態已發佈 - 1月 2023

ASJC Scopus subject areas

  • 化學 (全部)
  • 環境化學
  • 化學工程 (全部)
  • 工業與製造工程

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