First-phase insulin secretion is positively correlated with alanine aminotransferase in young adults

Chung Ze Wu, Chang Hsun Hsieh, Chieh Hua Lu, Dee Pei, Jin Shuen Chen, Yen Lin Chen

研究成果: 雜誌貢獻文章同行評審

2 引文 斯高帕斯(Scopus)

摘要

Background. Type 2 diabetes (T2D) is known to be one of the most prevalent diseases, and its prevalence is significantly associated with age and metabolic syndrome (MetS). Few studies have been conducted on liver function, MetS and insulin secretion among young adults. Objectives. In the present study, we explored the relationship between the liver function enzyme - alanine aminotransferase (ALT) - and first-phase insulin secretion (FPIS) among young adults. Material and methods. There were 22,971 men and 28,740 women, aged 18-27 years, assigned to subgroups according to the presence of MetS and quartiles of ALT values. Simple correlation was applied to evaluate their relationship. The difference between the slopes of these relationships and FPIS were statistically analyzed with Chris's calculator. Results. Most values for metabolic parameters, including ALT and FPIS, were determined to be relatively high in individuals with MetS. By contrast, individuals with MetS had lower high-density-lipoprotein cholesterol (HDL-C) counts and FPIS. Similar results were observed in the quartiles of ALT. Significant positive results were also found in the linear model. Depending on the ALT level, the slope change of FPIS still demonstrated a positive correlation between ALT and FPIS. This correlation was stronger for men than for women. Conclusions. A positive correlation between ALT and FPIS exists among young adults. Moreover, this correlation was stronger for men than for women. Both the cause and the effect require further investigation.
原文英語
頁(從 - 到)35-40
頁數6
期刊Advances in Clinical and Experimental Medicine
30
發行號1
DOIs
出版狀態已發佈 - 2021

ASJC Scopus subject areas

  • 內科學
  • 醫藥(雜項)
  • 評論和參考(醫學)
  • 一般生物化學,遺傳學和分子生物學
  • 遺傳學(臨床)
  • 藥學(醫學)

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