TY - JOUR
T1 - Fermented Rice Bran Mitigated the Syndromes of Type 2 Diabetes in KK-Ay Mice Model
AU - Agista, Afifah Zahra
AU - Kato, Ami
AU - Goto, Tomoko
AU - Koseki, Takuya
AU - Oikawa, Akira
AU - Ohsaki, Yusuke
AU - Yamaki, Michiko
AU - Yeh, Chiu Li
AU - Yang, Suh Ching
AU - Ardiansyah,
AU - Budijanto, Slamet
AU - Komai, Michio
AU - Shirakawa, Hitoshi
N1 - Publisher Copyright:
© 2024 by the authors.
PY - 2024/11
Y1 - 2024/11
N2 - Background: Diabetes is a devastating disease that causes millions of deaths. Fermented rice bran (FRB), made by fermenting rice bran with Aspergillus kawachii and a mixture of lactic acid bacteria, was hypothesized to b able to improve diabetes-related symptoms. This study aimed to investigate the effects of FRB supplementation in mitigating type 2 diabetes symptoms and identifying FRB bioactive compounds. Methods: In this study, KK-Ay mice (4 w.o. male) were used as a model for type 2 diabetes. Mice were divided into three different groups. The first group received a control diet, the second received a 12.5% non-fermented rice bran (RB) supplemented diet, and the last group was fed a 12.5% FRB-supplemented diet. Supplementation was done for 4 weeks. Results: FRB supplementation lowered the blood glucose level, OGTT, HOMA-IR, total cholesterol, liver RAGE protein, and glucokinase in KK-Ay mice. Metabolome analysis of RB and FRB showed that fermentation increased bioactive compounds in rice bran, such as GABA, L-theanine, and carnitine. It also increased the levels of various free amino acids while converting some amino acids such as arginine, tyrosine, and tryptophan into other metabolites. Conclusions: This research showed the potency of FRB supplementation as a preventive agent against type 2 diabetes.
AB - Background: Diabetes is a devastating disease that causes millions of deaths. Fermented rice bran (FRB), made by fermenting rice bran with Aspergillus kawachii and a mixture of lactic acid bacteria, was hypothesized to b able to improve diabetes-related symptoms. This study aimed to investigate the effects of FRB supplementation in mitigating type 2 diabetes symptoms and identifying FRB bioactive compounds. Methods: In this study, KK-Ay mice (4 w.o. male) were used as a model for type 2 diabetes. Mice were divided into three different groups. The first group received a control diet, the second received a 12.5% non-fermented rice bran (RB) supplemented diet, and the last group was fed a 12.5% FRB-supplemented diet. Supplementation was done for 4 weeks. Results: FRB supplementation lowered the blood glucose level, OGTT, HOMA-IR, total cholesterol, liver RAGE protein, and glucokinase in KK-Ay mice. Metabolome analysis of RB and FRB showed that fermentation increased bioactive compounds in rice bran, such as GABA, L-theanine, and carnitine. It also increased the levels of various free amino acids while converting some amino acids such as arginine, tyrosine, and tryptophan into other metabolites. Conclusions: This research showed the potency of FRB supplementation as a preventive agent against type 2 diabetes.
KW - Aspergillus kawachii
KW - diabetes
KW - fermented rice bran
KW - lactic acid bacteria
KW - Aspergillus kawachii
KW - diabetes
KW - fermented rice bran
KW - lactic acid bacteria
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U2 - 10.3390/metabo14110614
DO - 10.3390/metabo14110614
M3 - Article
AN - SCOPUS:85210382116
SN - 2218-1989
VL - 14
JO - Metabolites
JF - Metabolites
IS - 11
M1 - 614
ER -