TY - JOUR
T1 - Fatal hypereosinophilia with chromosome 15q- in a patient with multiple primary and familial neoplasms
AU - Goffman, Thomas E.
AU - Mulvihill, John J.
AU - Carney, Desmond N.
AU - Triche, Timothy J.
AU - Whang-Peng, Jacqueline
PY - 1983/1/1
Y1 - 1983/1/1
N2 - A man with large-cell carcinoma of the lung, cerebral meningioma, occult adenocarcinoma of the prostate, and follicular adenoma of the thyroid developed symptomatic, rapidly progressive hypereosinophilia with abnormalities of eosinophil ultrastructure and bone marrow karyotype (45,X,15q22-). Although the patient's eosinophilia defied strict classification as idiopathic hypereosinophilic syndrome (HES), simple tumor-associated eosinophilia, or eosinophilic leukemia, it appeared to be incited by the lung cancer and quickly acquired malignant independence. The family had an excess of prostate cancer and lymphoproliferative neoplasms.
AB - A man with large-cell carcinoma of the lung, cerebral meningioma, occult adenocarcinoma of the prostate, and follicular adenoma of the thyroid developed symptomatic, rapidly progressive hypereosinophilia with abnormalities of eosinophil ultrastructure and bone marrow karyotype (45,X,15q22-). Although the patient's eosinophilia defied strict classification as idiopathic hypereosinophilic syndrome (HES), simple tumor-associated eosinophilia, or eosinophilic leukemia, it appeared to be incited by the lung cancer and quickly acquired malignant independence. The family had an excess of prostate cancer and lymphoproliferative neoplasms.
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U2 - 10.1016/0165-4608(83)90135-8
DO - 10.1016/0165-4608(83)90135-8
M3 - Article
C2 - 6297705
AN - SCOPUS:0020576294
SN - 0165-4608
VL - 8
SP - 197
EP - 202
JO - Cancer Genetics and Cytogenetics
JF - Cancer Genetics and Cytogenetics
IS - 3
ER -
