Fasting serum long-acting natriuretic peptide correlates with the ankle brachial index in renal transplant recipients

Guan Jin Ho, Yen Cheng Chen, Wen Yao Yin, Yao Jen Chang, Ming Che Lee, Bang Gee Hsu

研究成果: 雜誌貢獻文章同行評審

3 引文 斯高帕斯(Scopus)

摘要

Objectives: Peripheral arterial diseases associated with an increased risk of death in kidney transplant patients. Natriuretic peptide has anti-atherosclerotic effects. We sought to evaluate the relation between ankle-brachial index and fasting serum long-acting natriuretic peptide concentrations in kidney transplant patients. Materials and Methods: Fasting blood samples were obtained from 69 kidney transplant patients. Serum long-acting natriuretic peptide concentrations were measured using a commercially available enzyme immunoassay kit. Left or right ankle-brachial index values that were < 0.9 were included in the low ankle-brachial index group. Results: Fifteen patients (21.7%) were enrolled in the low ankle-brachial index group. Increased waist circumference (P-.013), higher serum total cholesterol levels (P -.019), higher triglyceride levels (P -.002), and decreased serum long-acting natriuretic peptide concentrations (P -.006) were noted in the low ankle-brachial index group. Univariate linear regression analysis indicated that the left/right ankle-brachial index values of the subjects were negatively correlated with serum triglycerides (P -.008 or P <.001) and fasting glucose levels (P -.034 or P -.012), but were positively correlated with long-acting natriuretic peptide concentrations (P -.011 or P -.011). Multivariate forward stepwise linear regression analyses of the significant variables revealed that serum triglycerides and long-acting natriuretic peptide levels were independent predictors of the left/right anklebrachial index values of kidney transplant patients. Conclusions: Serum long-acting natriuretic peptide concentrations correlate positively with anklebrachial index values among the kidney transplant patients.

原文英語
頁(從 - 到)303-309
頁數7
期刊Experimental and Clinical Transplantation
11
發行號4
DOIs
出版狀態已發佈 - 8月 2013
對外發佈

ASJC Scopus subject areas

  • 移植

指紋

深入研究「Fasting serum long-acting natriuretic peptide correlates with the ankle brachial index in renal transplant recipients」主題。共同形成了獨特的指紋。

引用此